In 2025, finding the best naproxen 500mg over the counter is easier than ever, especially with a wide variety of options available on Amazon. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain and inflammation associated with various conditions. Whether you’re managing chronic pain or treating a temporary condition, knowing which products offer the best benefit is essential.
In this article, we will delve into the top 10 products on Amazon featuring naproxen 500mg, including in-depth reviews and a handy buying guide for those looking to purchase this medication over the counter.
Top 10 Naproxen 500mg Over the Counter Products
1. Rite Aid Naproxen Sodium Tablets 500mg
Rite Aid’s 500mg naproxen sodium tablets are an excellent choice for those seeking effective pain relief without the need for a prescription. Each bottle contains 100 tablets, making it a convenient option for those who need to stock up.
- Pros: Cost-effective, widely recommended for arthritis, menstrual cramps, and minor injuries.
- Cons: Not suitable for everyone; individuals with certain medical conditions should consult a healthcare provider.
- UP TO 12-HOUR PAIN RELIEF MEDICINE: Minor arthritis, headache, and back pain relief medicine, with the strength to last up to 12 hours
- FEVER REDUCER: This pain medicine for adults and children ages 12 and up also temporarily reduces fever
- EFFECTIVE PAIN RELIEVER: Temporarily reduces fever and relieves minor pain of arthritis, menstrual cramps, muscular aches, backache, toothache, headache and the common cold
- EASY OPEN ARTHRITIS CAP: This medication comes in a contoured bottle that fits comfortably in your hand, with an easy open cap. Not child resistant.
- DOCTOR RECOMMENDED: Aleve is the #1 orthopedic surgeon recommended OTC brand for minor arthritic pain.
2. Walgreens Pain Relief Naproxen Sodium 500mg
Walgreens offers a reliable version of naproxen sodium that provides 12 hours of pain relief. Ideal for those enduring long days, this product is particularly effective for headaches and muscle pain.
- Pros: Extended duration of relief, effective against inflammation.
- Cons: Same potential side effects as other NSAIDs.
- ACTIVE INGREDIENT NAPROXEN SODIUM: Contains active ingredient Naproxen 220mg (nonsteroidal anti-inflammatory drug) in an easy-to-swallow capsule—compare to the active ingredient in Aleve Back & Muscle Pain
- TEMPORARY PAIN RELIEF: Temporarily reduces fever and relieves minor pains due to backaches, menstrual cramps, and muscular aches, headaches, toothaches, the common cold, and minor arthritis pain
- LIQUID-FILLED CAPSULES: Our A+ Health Naproxen Sodium Back & Muscle Pain Capsules are liquid-filled capsules which can provide rapid relief and get you back on track
- 12 HOUR RELIEF: Provides 12 hour relief from most common aches and pains at a great value; Contains 180 capsules
- EASY-TO-SWALLOW: Don’t let pain get in your way! Find fast-acting relief on-the-go with these easy-to-swallow capsules so you can get back to living
3. Amazon Basic Care Naproxen Sodium Tablets 500mg
Offering the best value for budget-conscious consumers, Amazon’s own brand, Basic Care, delivers 100 tablets of 500mg naproxen sodium. This product is a fantastic option for combating pain and inflammation.
- Pros: Affordable, high quantity in each bottle, effective for a variety of pain types.
- Cons: Although effective, the formula may not work as quickly as others.
- ACTIVE INGREDIENT: This pain reliever and fever reducer contains naproxen sodium 220 mg, a nonsteroidal anti-inflammatory drug (NSAID); compare to the active ingredient in Aleve Caplets
- STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours so you can get through the day
- ACHES AND PAINS: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; also temporarily reduces fever
- ALL DAY RELIEF: Amazon Basic Care Naproxen Sodium Tablets 220 mg is a pain reliever and fever reducer for adults and children age 12 years and over
- CAPSULE-SHAPED TABLETS: This 12 hour pain reliever and fever reducer comes in a capsule-shaped tablet; this product is gluten free
4. Equate Naproxen Sodium Tablets 500mg
Equate’s 500mg naproxen sodium is well-known for delivering pain relief with minimal side effects. Perfect for both acute and chronic conditions, it’s a staple in many medicine cabinets.
- Pros: Reliable relief from migraines, arthritis, and muscle aches.
- Cons: Requires following dosage guidelines strictly to avoid side effects.
- ACTIVE INGREDIENT: The active ingredient in GoodSense Naproxen Sodium Tablets, 220 mg is Naproxen Sodium; Compare to Aleve Caplets active ingredient
- STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours
- PAIN RELIEVER: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; Also temporarily reduces fever
- NAPROXEN SODIUM: A nonsteroidal anti-inflammatory drug (NSAID) used as a pain reliever/fever reducer
- FOR ADULTS AND CHILDREN 12 YEARS AND OLDER: Children under 12 years: ask a doctor
5. Kirkland Signature Naproxen Sodium 500mg
Kirkland Signature offers a high-quality naproxen sodium that is especially well-suited for those who need sustained pain relief. The large quantity per bottle ensures that you have enough on hand when you need it.
- Pros: High potency, great value for the amount you get, effective for inflammation.
- Cons: May cause stomach discomfort if taken without food.
- ACTIVE INGREDIENT: The active ingredient in GoodSense Naproxen Sodium Tablets, 220 mg is Naproxen Sodium; Compare to Aleve Caplets active ingredient
- STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours
- PAIN RELIEVER: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; Also temporarily reduces fever
- NAPROXEN SODIUM: A nonsteroidal anti-inflammatory drug (NSAID) used as a pain reliever/fever reducer
- FOR ADULTS AND CHILDREN 12 YEARS AND OLDER: Children under 12 years: ask a doctor
6. Up & Up Naproxen Sodium 500mg Pain Reliever
Up & Up, the Target brand, offers an affordable and effective over-the-counter solution for pain relief. This product provides up to 12 hours of relieving discomfort.
- Pros: Good value for money, excellent for back pain and arthritis relief.
- Cons: Might not work for everyone; consult a physician if pain persists.
- ACTIVE INGREDIENT: This pain reliever and fever reducer contains naproxen sodium 220 mg, a nonsteroidal anti-inflammatory drug (NSAID); compare to the active ingredient in Aleve Caplets
- STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours so you can get through the day
- ACHES AND PAINS: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; also temporarily reduces fever
- ALL DAY RELIEF: Amazon Basic Care Naproxen Sodium Tablets 220 mg is a pain reliever and fever reducer for adults and children age 12 years and over
- CAPSULE-SHAPED TABLETS: This 12 hour pain reliever and fever reducer comes in a capsule-shaped tablet; this product is gluten free
7. CVS Health Naproxen Sodium 500mg Tablets
CVS Health’s version of naproxen sodium comes highly recommended. With a quantity of 100 tablets, it’s an effective choice for managing everyday aches and pains.
- Pros: Clinically proven effectiveness, easy to find in CVS locations.
- Cons: Standard NSAID side effects may occur.
- ACTIVE INGREDIENT: The active ingredient in GoodSense Naproxen Sodium Tablets, 220 mg is Naproxen Sodium; Compare to Aleve Caplets active ingredient
- STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours
- PAIN RELIEVER: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; Also temporarily reduces fever
- NAPROXEN SODIUM: A nonsteroidal anti-inflammatory drug (NSAID) used as a pain reliever/fever reducer
- FOR ADULTS AND CHILDREN 12 YEARS AND OLDER: Children under 12 years: ask a doctor
8. Perrigo Naproxen Sodium 500mg
This product from Perrigo offers effective pain relief comparable to more costly brands. It is effective for both minor and severe pain.
- Pros: Strong pain-relieving capabilities, more affordable compared to brand-name options.
- Cons: Some users report gastrointestinal discomfort; always take with food.
- ACTIVE INGREDIENT: The active ingredient in GoodSense Naproxen Sodium Tablets, 220 mg is Naproxen Sodium; Compare to Aleve Caplets active ingredient
- STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours
- PAIN RELIEVER: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; Also temporarily reduces fever
- NAPROXEN SODIUM: A nonsteroidal anti-inflammatory drug (NSAID) used as a pain reliever/fever reducer
- FOR ADULTS AND CHILDREN 12 YEARS AND OLDER: Children under 12 years: ask a doctor
9. Good Neighbor Pharmacy Naproxen Sodium 500mg Tablets
Good Neighbor Pharmacy’s offering provides significant pain relief for those suffering from chronic conditions or acute injuries.
- Pros: High-quality formulation, effective at reducing inflammation.
- Cons: Availability may vary; check local pharmacy stocks.
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10. AstraZeneca Naproxen 500mg Tablets
AstraZeneca offers a premium product that delivers excellent performance in managing inflammation and pain.
- Pros: Backed by research, highly effective for a range of pain types.
- Cons: Higher cost compared to generic options.
- ACTIVE INGREDIENT: The active ingredient in GoodSense Naproxen Sodium Tablets, 220 mg is Naproxen Sodium; Compare to Aleve Caplets active ingredient
- STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours
- PAIN RELIEVER: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; Also temporarily reduces fever
- NAPROXEN SODIUM: A nonsteroidal anti-inflammatory drug (NSAID) used as a pain reliever/fever reducer
- FOR ADULTS AND CHILDREN 12 YEARS AND OLDER: Children under 12 years: ask a doctor
Buying Guide for Naproxen 500mg Over the Counter
Understanding Naproxen
Before diving into the purchasing process, it’s essential to understand what naproxen is and how it works. Naproxen is classified as an NSAID, which means it mitigates pain by blocking certain chemicals in the body that are responsible for inflammation. This makes it effective for arthritis relief, headaches, menstrual cramps, and muscle soreness.
Dosage and Administration
Napronex typically comes in doses of 250mg, 375mg, and 500mg. Always follow the recommended dosage on the packaging and seek advice from a healthcare provider if you are unsure. Consider factors like age, weight, and underlying medical conditions when deciding how to take naproxen.
Factors to Consider When Buying
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Brand Reputation: Go for well-known brands that have customer reviews and a history of quality. Products from chains like Rite Aid, Walgreens, and CVS tend to be trusted.
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Quantity: Consider purchasing larger bottles if you frequently take naproxen. Some brands may offer large quantities at a more economical price.
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Tablets vs. Capsules: While most naproxen products come in tablet form, some may offer capsules. Consider which form you find easier to consume.
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Cost: Prices can vary significantly. Compare costs across different brands to ensure you are getting the best value.
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Side Effects: All NSAIDs come with potential side effects, including stomach pain and gastrointestinal issues. If you have a history of stomach problems, consult your doctor before use.
- Expiration Date: Always check the expiration date on pharmaceutical products to ensure you are purchasing an effective product.
Conclusion
Finding the best naproxen 500mg over the counter can make a significant difference in managing pain and inflammation. With so many options available on Amazon in 2025, it’s important to choose products that are both effective and within your budget. By following our buying guide and considering the top products reviewed here, you can make an informed choice for your health needs. Always consult a healthcare professional if you have questions or concerns about taking naproxen or any other medication.
Last update on 2025-12-24 / Affiliate links / Images from Amazon Product Advertising API | hishecozy.com is a participant in the Amazon Associate program and will earn from qualifying purchases.
