Best Muscle and Joint Pain Relief Cream for 2025: Top Products to Try

When it comes to alleviating muscle and joint pain, finding the right cream can be pivotal for your comfort and daily functionality. In this article, we will showcase the best muscle and joint pain relief creams available on Amazon in 2025. Our carefully curated list comprises ten exceptional products aimed at providing effective pain relief.

OFF -$5.02Bestseller No. 1
Blue Emu Cream, 1 Pack 12 oz
  • Blue-Emu is the go to brand for America's #1 Emu Oil Formula. The naturally powerful carrier oil allows ingredients such as Aloe Vera, MSM & Glucosamine absorb directly to your tired joints and muscles.
  • Multiple use application! Apply to back, neck, shoulders, elbows, wrists, knees, hips, feet, hands, and ankles for daily soothing assistance.
  • Get rid of that menthol stench. Our emu-oil based cream is odor free and is a non-greasy application. Irritation free!
  • The deep penetrating cream gets below the skin in a hurry, no need to wait long periods of time for the soothing formula to kick in!
  • Daily application is not only safe, it's recommended! Apply liberally 2-3 times daily for two weeks, and then as needed. In addition to soothing benefits, use the 12oz Original Super Strength Cream to help dry, chapped or weathered skin.
Bestseller No. 2
Bengay Ultra Strength Topical Pain Relief Cream, Non-Greasy Topical Analgesic for Minor Arthritis, Muscle, Joint and Back Pain, Camphor, Menthol and Methyl Salicylate, 4 OZ
  • 4-ounce tube of non-greasy Bengay Ultra Strength Topical Pain Relief Cream with three powerful ingredients to ease backaches, minor arthritis, muscle, and joint pain
  • Topical analgesic cream provides relief from muscle aches and joint pain. It contains three pain-relieving ingredients for powerful relief at the site of pain: 4% camphor, 10% menthol, and 30% methyl salicylate
  • Pain relief cream provides temporary relief from minor aches and pains of muscles and joints associated with simple backaches, minor arthritis pains, strains, bruises, and muscle sprains
  • Bengay, a physician-recommended OTC topical analgesic brand, contains more pain-relieving ingredients than any other Bengay product. Adults and children 12 years and older, apply to the affected area no more than three to four times daily
  • Pack the topical pain relief analgesic in a convenient tube in your gym bag or suitcase for port-able & on-the-go relief from aches, minor arthritis, joint, and back pain
Bestseller No. 3
Biofreeze Pain Relief Cream for Knee, Neck, Hip, Joint, Shoulder, & Simple Backache, Arthritis Pain Reliever, Sore Muscle Relief, Cooling Menthol Pain Cream, 3 Oz
  • PAIN RELIEVER: Enjoy cooling pain relief with Biofreeze, the #1 clinician recommended menthol topical pain relief brand*; Helps relieve minor aches & pains of muscles & joints associated with simple backache, arthritis, strains, bruises & sprains
  • LOWER BACK PAIN RELIEF: Ideal for both athletes & everyday ache sufferers, our non-greasy pain relief cream provides targeted menthol pain relief for simple backache; Also helps relieve soreness during muscle recovery
  • NECK PAIN RELIEF: Relieve neck pain with Biofreeze; Trusted by chiropractors, podiatrists, physical therapists, massage therapists, retail pharmacists, & athletic trainers
  • FAST-ACTING BIOFREEZE CREAM WITH NATURAL MOISTURIZERS: When you're in pain, you need a fast-acting formula that works - Biofreeze delivers cooling, targeted relief and won't wear off quickly, so you can get back to your best
  • SHOULDER PAIN RELIEF: Whether you have pain from a bruise, arthritis, or an intense workout, our moisturizing pain relief cream powered by menthol stimulates cold receptors that create a cooling sensation, helping to relieve pain
OFF -$4.11Bestseller No. 4
Boiron Arnicare Gel for Relief of Joint Pain, Muscle Pain, Muscle Soreness, and Swelling from Bruises or Injury - Non-greasy and Fragrance-Free - 2.6 oz
  • ARNICA FOR PAIN: This homeopathic medicine helps temporarily relieve muscle pain & stiffness due to minor injuries, overexertion & falls. Also great for pain, swelling, & discoloration from bruises.
  • TOPICAL PAIN RELIEF: Our non-greasy, water-based formula absorbs quickly & is unscented & paraben-free. This cooling gel is great for relief following an injury, intense workout, or general overexertion.
  • PLANT-BASED ACTIVE INGREDIENT: The Arnica montana plant is a natural pain reliever. This popular homeopathic medicine temporarily relieves muscle pain & stiffness without unwanted drowsiness. Fluoride-Free
  • HOMEOPATHIC MEDICINE uses highly diluted biological, botanical, or mineral substances to relieve symptoms. Our tablets, pellets, & topical treatments work with your body without the risk of contraindications, or known drug interactions.
  • THE BOIRON PROMISE: We believe there’s more than one way to feel better. Since 1932, we have been committed to providing quality medicines. As a world leader in homeopathy, our passion is your health. Our promise is your satisfaction.
Bestseller No. 5
Penetrex Soothing Joint & Muscle Pain Relief Cream with Hemp - Deep Penetrating Menthol, Arnica and Hemp for Soothing, Hydrating Relief - Non-Greasy, Easy to Apply, Pleasant Scent- 2oz Squeezable Tube
  • DEEP PENETRATING PAIN RELIEF: From the makers of Penetrex comes a soothing addition to your relief regimen. Our non-prescription muscle pain relief cream provides soothing relief from aches and pains associated with arthritis, sprains & strains, and knee, neck, elbow, and back discomfort.
  • UNIQUE FORMULA: Pain relief cream made with our proprietary blend of ingredients; menthol soaks into the body and soothes while hemp and arnica provide moisturizing relief; boswellia serrata aids with overall joint health supplemented by vitamin B6
  • PLEASANT, SOOTHING COMFORT: This premium, non-greasy hemp cream lightly soothes and provides moisturizing comfort for joints and muscles; joint pain relief cream made with a mild, pleasant scent that disappears with time
  • USAGE: Hemp cream (maximum strength) temporarily relieves minor aches and pains associated with backache, arthritis, strains, bruises and sprains; apply to affected area no more than 3-4 times per day
  • TRUST IN PENETREX: Enabling you to get back to your favorite activities with the premium experience in joint & muscle relief; eliminate the limitations of joint and muscle discomfort with Penetrex
Bestseller No. 6
HEMPACTIV Hemp Cream with Menthol, MSM & Arnica – Lightweight, Fast-Absorbing Moisturizing Cream – Refreshing, Non-Greasy Formula for Nourished Skin – 2 Fl Oz
  • Premium Botanical Blend – Crafted with natural ingredients including hemp seed oil, arnica, MSM, and menthol to help keep your skin hydrated and refreshed.
  • Lightweight & Non-Greasy – Designed for quick absorption, leaving skin smooth, soft, and comfortable without residue.
  • Daily Moisturizing Care – Ideal for hands, legs, feet, and other areas needing hydration and conditioning.
  • Refreshing Skin Experience – Menthol provides a clean, cooling feel while supporting your skin’s natural balance.
  • HEMPACTIV Commitment – Proudly made with care using quality ingredients. Free from parabens, dyes, silicones, and harsh chemicals.
Bestseller No. 7
Hemp Cream - Maximum Strength Lotion to Soothe Discomfort - Gel with Arnica, Glucosamine, MSM, Menthol, Aloe Vera, Hemp Oil, Turmeric - Fast Absorption, Long-Lasting, Non-Greasy, Pleasant Scent - 4 oz
  • Fast-Acting Cream: experience rapid comfort with our hemp cream's lightweight, non-greasy formula that absorbs quickly, providing natural soothing care in a few minutes.
  • Targeted Support for Discomfort: our hemp cream is a perfect sollution for alleviating a discomfort in specific areas of your body without causing any irritation.
  • Gentle Ingredients: our hemp cream is enriched with natural ingredients - arnica, boswellia, aloe, menthol, turmeric. All of them are combined together for your comfort without negative reactions.
  • Brand Quality: produced with high-quality, non-GMO and gluten-free components, this hemp cream deeply hydrates the skin while delivering the long-lasting comfort with every application.
  • Easy to Use: massage a small amount onto affected area 3-4 times a day for better effect. Wash hands with a warm water after applying to skin. Store the cream in the cool, dark place.
Bestseller No. 8
Sub Zero Cooling Pain Relief Gel, 3oz Roll-On - Joint Relief and Nerve Pain Relief Cream for Muscle Deep Pain Relief, Back Pain Relief Products
  • Cooling Gel Pain Relief... Sub Zero Pain Relief Gel delivers effective & fast pain relief due to strenuous exercise, sore muscles, strains, spasms, stress & more. Pain relief gel is colorless and a non-greasy formula for long-lasting pain relief.
  • Fast-acting pain relief... Sub Zero pain relief gel contains menthol gel, cat's claw herb & a unique blend of other herbs to provide immediate & penetrative pain relief. Our pain relief gel is great for muscle pain, joint relief, nerve pain, & more
  • Sore Muscle Relief.... Sore from lifting and need a muscle rub? Need arthritis pain relief from a strenuous hike? Need back pain relief from yard work? Keep SubZero close to provide advanced fast cooling pain relief where you need it, when you need it
  • Multi-Sizes Pain Relief Gel.... Cooling gel is a pain reliever available in a variety of sizes. Look for our pain cream gel in 5g travel packs, 3-oz. pain relief roll on pain relief, 16 oz tube, 1 gallon, and 4-oz. tube for convenient on the go use
  • Sub Zero Quality.... Compare the active ingredients and pain relief of Sub Zero against other major numbing cream or gels and you will be pleased with less pain. Also works for fibromyalgia pain relief and for joint pain relief
Bestseller No. 9
Advil Targeted Relief Pain Relieving Cream, Up to 8 Hours of Powerful Relief of Minor Arthritis Pain, Joint Pain, Lower Back Pain and Muscle Pain - 2.3 oz
  • One 2.3 oz Tube of Advil Targeted Relief Pain Relieving Cream - The only topical pain reliever with 4 powerful pain-fighting ingredients (1)
  • Provides a warming & cooling sensation on contact and lasts up to 8 hours (1)
  • Designed to quickly tackle pain four ways: targets, penetrates, blocks, and relieves
  • Fast and powerful relief for minor arthritis pain, muscle, joint and back pain - the perfect addition to your college dorm room essentials
  • Doesn't leave your skin feeling dry or greasy and easily glides onto skin, ensuring comfort with every use
OFF -$3.01Bestseller No. 10
Advil Targeted Relief Pain Relieving Cream with Massage Applicator, Up to 8 Hours of Powerful Relief of Minor Arthritis Pain, Joint Pain, Lower Back Pain and Muscle Pain, 2.5 oz
  • One 2.5 oz Advil Targeted Relief Pain Relieving Cream with Massage Applicator - The only topical pain reliever with 4 powerful pain-fighting ingredients (1)
  • Provides a warming & cooling sensation on contact and lasts up to 8 hours (1)
  • Designed to quickly tackle pain four ways: targets, penetrates, blocks, and relieves
  • Fast and powerful relief for minor arthritis pain, muscle, joint and back pain - the perfect addition to your college dorm room essentials
  • Massaging head for deep relief and glides on easy, ensuring comfort with every use

Muscle and joint pains are common issues faced by many, whether due to age, overexertion, or chronic conditions. Here, we’ll review the top-rated options that not only promise relief but also bring effective ingredients into the mix.

Top 10 Muscle and Joint Pain Relief Creams

1. Biofreeze Pain Relief Gel

Biofreeze Pain Relief Gel has been a go-to choice among athletes and active individuals. This topical analgesic provides a cooling sensation, bringing quick relief from localized pain. It is formulated with menthol, a natural ingredient that promotes enhanced blood flow to the area.

Key Features:

  • Fast-acting formula
  • Menthol-based for a cooling effect
  • Non-greasy and easy to apply

Pros:

  • Quick absorption
  • No strong odor
  • Suitable for all ages

Cons:

  • Requires frequent application for lasting relief

The efficacy of Biofreeze has made it a recognized product in the world of pain relief. Users appreciate its non-greasy feel, making it easy to use throughout the day without worrying about staining clothes.

Bestseller No. 1
Biofreeze Pain Relief Gel, Arthritis Pain Reliver, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Pharmacist Recommended, FSA Eligible, 3 FL OZ Biofreeze Menthol Gel
  • #1 Clinically Recommended Menthol Topical Pain Relief Brand
  • This 3 fl oz gel tube is one of the most popular formats, well-suited for application on small and large muscle areas
  • Biofreeze is a clinically recommended brand; trusted by pharmacists, physical therapists, chiropractors, massage therapists, podiatrists, and athletic trainers
  • Product is not tested on animals, made with USP grade menthol, and free of NSAIDs
  • Product is not tested on animals, made with USP grade menthol, and free of NSAIDs

2. Arnicare Pain Relief Cream

Arnicare Pain Relief Cream is a homeopathic remedy that utilizes arnica montana, a plant known for its anti-inflammatory properties. It is designed to soothe muscle soreness, reduce swelling, and promote healing after a workout or injury.

Key Features:

  • Non-greasy cream
  • Absorbs quickly
  • No artificial fragrances or dyes

Pros:

  • Safe for sensitive skin
  • Great for bruises and sprains
  • Helps reduce muscle stiffness

Cons:

  • May take time for noticeable effects

Users often share positive experiences, particularly highlighting its effectiveness in treating bruises and minor muscle strains. The absence of strong fragrances allows it to be more pleasant for everyday use.

OFF -$5.07Bestseller No. 1
Boiron Arnicare Cream for Joint Pain, Muscle Pain, Swelling, Soreness, Stiffness, and Bruises - Fast Absorbing and Fragrance-Free - 4.2 oz
  • ARNICA FOR PAIN: This homeopathic medicine helps temporarily relieve muscle pain & stiffness due to minor injuries, overexertion & falls. Also great for pain, swelling, & discoloration from bruises.
  • TOPICAL PAIN RELIEF: Our non-greasy, light & soothing cream is unscented & paraben-free. This moisturizing formula is great for relief following an injury, intense workout, or general overexertion.
  • PLANT-BASED ACTIVE INGREDIENT: The Arnica montana plant is a natural pain reliever. This popular homeopathic medicine temporarily relieves muscle pain & stiffness without unwanted drowsiness.
  • HOMEOPATHIC MEDICINE uses highly diluted biological, botanical, or mineral substances to relieve symptoms. Our tablets, pellets, & topical treatments work with your body without the risk of contraindications, or known drug interactions.
  • THE BOIRON PROMISE: We believe there’s more than one way to feel better. Since 1932, we have been committed to providing quality medicines. As a world leader in homeopathy, our passion is your health. Our promise is your satisfaction.

3. Tiger Balm Analgesic Ointment

Tiger Balm has been a household name for muscle and joint pain relief. This ointment combines menthol and camphor to provide both cooling and warming effects, subsequently easing discomfort.

Key Features:

  • Dual-action formula
  • Strong, aromatic scent
  • Effective for various types of pain

Pros:

  • Long-lasting relief
  • Affordable option
  • Versatile for different pain types

Cons:

  • Strong smell may not appeal to everyone

The scent of Tiger Balm can be polarizing, but many users find that the strong aroma pairs well with its potent pain-relieving capabilities. It’s an excellent choice for those who endure chronic pain conditions.

OFF -$0.91Bestseller No. 1
TIGER BALM TIGER BALM,X-STRNG,RED, 18 GRM
  • Natural Ingredients: Made with natural ingredients like tiger balm, Arnica Montana Flower, and Calendula Officinalis
  • Relieves Pain: Reduces pain and inflammation thanks to the natural ingredients
  • Moisturizing: Leaves skin feeling soft and smooth with its moisturizing properties
  • For All Skin Types: Suitable for all skin types and won't clog pores
  • Convenient Size: 18 grams of tiger balm in a handy tube for on-the-go use

4. Voltaren Arthritis Pain Gel

Voltaren has made waves in the pain relief industry, particularly for its effectiveness in treating arthritis pain. This topical NSAID (non-steroidal anti-inflammatory drug) penetrates deep into the tissue, targeting inflammation.

Key Features:

  • Prescription-strength formula
  • Non-greasy gel
  • Proven efficacy for arthritis pain

Pros:

  • Clinically tested
  • Offers targeted relief
  • Easy to apply

Cons:

  • Not ideal for acute pain or sports injuries

The comprehensive relief that Voltaren provides makes it a favorite for arthritis sufferers. Users find that its long-lasting effects allow them to live their lives with minimal interference from pain.

Bestseller No. 1
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2
  • Two 3.5 oz/100 g tubes of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
  • Number 1 Doctor Recommended topical pain relief brand
  • Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
  • An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management*
  • Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain

5. Aspercreme with Lidocaine

Aspercreme offers a unique approach to pain relief by incorporating lidocaine into its formula. This cream numbs the area, making it effective for nerve-related pain and localized discomfort.

Key Features:

  • Numbing effect with lidocaine
  • Odor-free formula
  • Fast-acting relief

Pros:

  • Suitable for sensitive skin
  • Non-greasy texture
  • Great for neuropathic pain

Cons:

  • Limited to external use only

For those dealing with nerve pain, Aspercreme is a top contender. Its odor-free formula and numbing sensation make it a comfortable choice for individuals who are sensitive to scent.

OFF -$4.01Bestseller No. 1
Aspercreme Lidocaine Pain Relief Cream Soothes Aggravated Nerves, Numbing Topical Analgesic with Max-Strength 4% Lidocaine & Moisturizing Aloe, 4.3 Oz.
  • Contains one (1) 4.3-oz. tube of Aspercreme Pain Relief Cream With Max-Strength Lidocaine and Moisturizing Aloe
  • Fast-Acting Relief: Experience rapid and lasting pain relief with max-strength 4% lidocaine topical numbing cream, designed to target nerves and numb away pain
  • Non-greasy Formula: Fragrance-free Aspercreme moisturizes and relieves without greasy residue or strong odor
  • Maximum-Strength Lidocaine: OTC Aspercreme offers the maximum-strength lidocaine pain relief available without a prescription and is FSA/HSA eligible
  • Travel-Size: Take your pain relief solution on the go in a compact and portable tube

6. Sombra Warm Therapy Pain Relieving Gel

Sombra brings forth a warm therapy approach, featuring active ingredients that help soothe deep tissue pain. This gel is beneficial for individuals who have chronic tension or muscle stiffness.

Key Features:

  • Creates a warming sensation
  • Made with natural ingredients
  • Aloe Vera enriched formula

Pros:

  • Reduces muscle tension
  • Pleasant aroma
  • Non-greasy application

Cons:

  • Can feel too hot for some users

Users frequently commend Sombra for its warming effect that penetrates deep into the muscle, promoting relaxation and increased blood flow. The natural ingredients add to its appeal and effectiveness.

Bestseller No. 1
Sombra Warm Pain Relief Gel, Warm Relief for Arthritis and Chronic Pain Pre-Workout Muscle Rub Vegan Formula Free of Artificial Fragrances, Dyes, NSAIDs, Wax, Petroleum, Alcohol - 8oz Jar
  • TRIED AND TRUE PAIN RELIEF FOR 5+ DECADES | For Over 50 Years, Our Family-Owned Business Has Provided You With High-Quality Products You Can Trust | From Pre-Workout Tension Relief to Daily Arthritis Care, Our Original Warm Therapy Gel Provides Relaxing, Available in Multiple Sizes & Dispense Options, You’ll be Ready to Relieve Pain from Anywhere
  • IDEAL FOR YOUR AT-HOME FIRST AID KIT | Ease Muscle Pain, Joint Sensitivity, & Pre-Workout Muscle Tension | Sombra’s Original Warm Therapy Gel Also Offers Quick Relief for Pain Due to Arthritis, Fibromyalgia, or Lupus Flares | Keep Our Roll-On Tube in Your Mobile First Aid Kit, and an 8 oz Jar in Your Kit at Home, For Complete Peace of Mind
  • PREMIUM-QUALITY, PLANT-DERIVED INGREDIENTS | Warming Camphor & Cooling Menthol Combine With Aloe Vera, Green Tea, Witch Hazel, Flowers, Herbs, & Other Plant Extracts to Provide Comfort & Relief | No Artificial Colors or Fragrances | Free From Dyes, Gluten, Waxes, Petroleum, Alcohol, NSAIDs, & Animal Products | Refreshing Lemon Scent
  • TRUSTED BY DOCTORS & CAREGIVERS NATIONWIDE | Get Clinical-Quality Relief, Over The Counter | Sold in Doctor’s Offices for Over 35 Years, Sombra Products Are Now Available to Individual Shoppers Through Popular Retailers | Our OTC Products Still Contain Powerful, 3% Camphor & Menthol For Exceptional Relief Without a Doctor’s Visit
  • GREAT FOR ATHLETES, HOBBYISTS, & SENIORS | Calm Muscle Tension Before Running, Weightlifting, Dancing, & Hiking | Soothe Cramps From Gaming Sessions, Crafting, Pickleball, Gardening, & Other Hobbies | Non-Staining, Vegan Formula is Easy to Apply & Acts Fast, So You Can Get Back to The Things That Matter Most to You

7. Imagine Pain Relief Cream

Imagine Pain Relief Cream is a premium option designed for athletes and active individuals. Formulated with menthol and other powerful ingredients, it offers cooling and heating sensations to combat pain.

Key Features:

  • Deep-penetrating action
  • Non-greasy, easy to apply
  • Formulated for sports injuries

Pros:

  • Provides fast relief
  • Works well on various pain types
  • Green tea extract for added antioxidants

Cons:

  • Slightly more expensive than competitors

Athletes often turn to Imagine for post-workout relief, appreciating the blend of cooling and heating sensations that helps ease muscle tightness.

OFF -$2.03Bestseller No. 1
MagniLife Leg & Back Pain Relief Cream, Fast-Acting Pain Relief, Naturally Soothe Burning, Tingling and Stabbing Pains with Aloe and Calendula - 4oz
  • HOW TO USE - Constant pain in your lower body can be distracting and debilitating. A pain reliever developed to specifically target symptoms in the lower back, buttocks and legs. Results may vary. For best results, this topical cream should be used twice daily for a sustained period of time, applying generously and massaging into skin to help ease burning, tingling and stabbing pains in your lower body.
  • INTENSE NATURAL INGREDIENTS - Naturally derived blend soothes aching, uncomfortable pain in legs and back with aloe, lavender, magnesium, geranium, sweet and chili peppers, colocynth and calendula. Our deep penetrating cream contains active ingredients to help deliver fast-acting, serious relief when you need it most.
  • NOTHING ADDED BUT THE GOOD STUFF - This quick absorbing, non-greasy cream penetrates deeply. Safe to use on sensitive skin with no added dyes or fragrances.
  • SAFE TO USE WITH OTHER PAIN RELIEVERS - Topical formulas can be used in conjunction with other OTC pain relievers or medications.
  • TRUSTED BRAND WITH YOU IN MIND - MagniLife has been a trusted business for over 25 years. All of our products are developed and manufactured in our state-of-the art facilities. Made with highly qualified formulators to ensure excellence in quality and consistency, we ensure top quality products and are dedicated to providing products that help to improve quality of life. Start your journey to a healthy lifestyle today!

8. Penetrex Pain Relief Cream

Penetrex Pain Relief Cream is known for its ability to alleviate pain without the use of harsh chemicals. It combines several natural ingredients to provide soothing relief from muscle and joint discomfort.

Key Features:

  • Non-toxic formula
  • Absorbs quickly
  • Pleasant scent

Pros:

  • Safe for daily use
  • Works well for chronic pain
  • Can be used for arthritis

Cons:

  • May require consistent application for results

Users appreciate Penetrex for its clean formulation and efficiency in soothing chronic pain. This cream is usually recommended for individuals seeking a natural alternative to conventional options.

OFF -$2.95Bestseller No. 1
Penetrex Joint & Muscle Therapy - Soothing Comfort for Back, Neck, Hands, Feet - Premium Whole Body Rub with Arnica, Vitamin B6 MSM & Boswellia - Non-Greasy 4oz Cream
  • Trusted Daily Relief for Back, Neck, Knee, Shoulder & Hand Discomfort – Non-NSAID Formula. Penetrex provides targeted support for common problem areas including lower back, stiff neck, achy knees, shoulder tension, and hand soreness. Formulated without NSAIDs (non-steroidal anti-inflammatory drugs) for those seeking natural alternatives to oral medications or medicated patches for routine joint and muscle strain.
  • Professional-Grade Ingredients: Arnica, MSM, Vitamin B6 & Boswellia for Enhanced Support. Enhanced with clinically-studied botanicals and nutrients recognized for their soothing properties. Arnica montana has been used traditionally for centuries, while MSM (Methylsulfonylmethane), Vitamin B6, and Boswellia Serrata work synergistically to support muscles and joints experiencing occasional discomfort from exercise, repetitive motion, or daily activity.
  • Fast-Absorbing, Non-Greasy Cream – No Menthol Smell, Won't Stain Clothing. Lightweight, fast-penetrating formula absorbs quickly into skin without leaving oily residue, sticky feeling, or transferring to clothes or bed sheets. Unlike menthol-based products with strong medicinal odors, Penetrex is fragrance-free with no overpowering scent, making it ideal for use anytime – at work, before bed, or during your daily routine.
  • Ideal for Active Adults, Athletes & Those Managing Chronic Tension – Safe for Long-Term Use. Perfect for fitness enthusiasts dealing with post-workout soreness, office workers with repetitive strain, aging adults experiencing stiffness, or anyone managing ongoing discomfort in joints and muscles. Gentle enough for consistent daily application without the concerns associated with prolonged NSAID use.
  • Trusted by Over 2 Million Users and Made in USA with Quality Standards You Can Count On. With a loyal customer base spanning over a decade, Penetrex has become a household name for natural topical support. Manufactured in the USA following strict quality standards, and suitable for those seeking vegan-friendly, paraben-free formulations.

9. Hot & Cold Pain Relief Gel

Hot & Cold Pain Relief Gel offers both cooling and warming sensations in one product. This dual-action approach is effective for both immediate and chronic pain relief.

Key Features:

  • Versatile temperature action
  • Long-lasting formula
  • Safe for the entire body

Pros:

  • Fast absorption
  • Ideal for sports injuries
  • Scent-free option

Cons:

  • Some users may find temperature changes overwhelming

Athletes find this gel particularly useful for treating localized injuries. The dual temperature action makes it unique compared to standard products on the market.

OFF -$1.99Bestseller No. 1
Magic Gel Ice Pack for Back Pain Relief | 2 Pack Reusable Lower Back Wrap for Hot or Cold Therapy | Relief for Lower Lumbar, Sciatic Nerve, Herniated or Degenerative Disc, Coccyx, Tailbone Pain
  • NO. 1 BACK DISCOMFORT SOLUTION: Using our versatile dual heat and cold packs for therapy is the best way to treat back discomfort. The heat pad and strap provide cool compression for upper and lower back issues.
  • SPECIALLY DESIGNED FOR YOUR BACK: The gel packs contour around your midriff, sides of your waist and fastens with a secure strap closure. The neoprene is breathable, so it doesn't cause any itching!
  • AIDING YOUR FAST RECOVERY: Studies have shown a cold pack helps with healing. Whether you are recovering from surgery or struggling with general discomfort, this reusable ice pack is designed to help.
  • FLEXIBLE FROM FROZEN: With the thickest viscosity gel, the pack remains pliable straight from the freezer. The flexibility allows the pack to contour around your back and sit against problem areas.
  • LONG-LASTING, SAFE HEATING - We recommend warm or hot use for muscle spasms and treatments. The gel packs can be warmed and stay warm for up to 18 minutes. It's safe and leak-free heat therapy!

10. Flexall Pain Relieving Gel

Flexall Pain Relieving Gel is formulated to address muscle and joint pain effectively. This gel combines menthol and aloe, providing a soothing experience that also hydrates the skin.

Key Features:

  • Non-greasy and easy to use
  • Fast-acting relief
  • Moisturizing properties

Pros:

  • Ideal for sports-related injuries
  • Works well for muscle cramps
  • Generous size for longer use

Cons:

  • Strong menthol scent may not appeal to everyone

Flexall users appreciate its fast-acting relief and moisturizing benefits, which sets it apart from other options. Athletes often recommend it for its effective formulation.

Bestseller No. 1
Biofreeze Pain Relief Gel, Arthritis Pain Reliver, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Pharmacist Recommended, FSA Eligible, 3 FL OZ Biofreeze Menthol Gel
  • #1 Clinically Recommended Menthol Topical Pain Relief Brand
  • This 3 fl oz gel tube is one of the most popular formats, well-suited for application on small and large muscle areas
  • Biofreeze is a clinically recommended brand; trusted by pharmacists, physical therapists, chiropractors, massage therapists, podiatrists, and athletic trainers
  • Product is not tested on animals, made with USP grade menthol, and free of NSAIDs
  • Product is not tested on animals, made with USP grade menthol, and free of NSAIDs

Buying Guide for Muscle and Joint Pain Relief Creams

Choosing the best muscle and joint pain relief cream can be challenging with so many products available. Here are factors to consider when making your choice:

Active Ingredients

Look for creams that contain proven ingredients like menthol, arnica, or lidocaine. Each ingredient works differently; menthol provides a cooling sensation, while lidocaine numbs pain.

Type of Pain

Consider what type of pain you are dealing with (acute, chronic, neuropathic, etc.). Some creams are better suited for specific pain types—like lidocaine for neuropathy.

Absorption and Texture

A non-greasy and quickly absorbing cream will provide ease of use in daily life. Check out reviews to see how well a product absorbs into the skin.

Scent

If you’re sensitive to scents, consider odor-free or lightly scented options. Strong odors can be off-putting, especially for everyday wear.

Skin Sensitivity

If you have sensitive skin, choose hypoallergenic creams and test a small spot before wider application. Products formulated without dyes and artificial fragrances are often gentler.

Price vs. Value

While some premium brands may seem pricey, consider the value they offer in long-term efficacy. Mid-range options can also provide effective relief without breaking the bank.

Choosing the best muscle and joint pain relief cream for your needs is essential for optimal comfort and functionality. Whether you are an athlete, an office worker, or someone managing chronic pain, there is a suitable option for you on Amazon.

Conclusion

With the variety of products available in 2025, anyone dealing with muscle and joint pain can find relief that fits their needs. Consider our top ten selections based on efficacy, user feedback, and formulation. Together, these creams form a reliable arsenal against pain, allowing individuals to live life more fully.

Last update on 2025-12-26 / Affiliate links / Images from Amazon Product Advertising API | hishecozy.com is a participant in the Amazon Associate program and will earn from qualifying purchases.

Evelyn Hawthorne
Evelyn Hawthorne