As a responsible pet owner, ensuring your dog’s health and well-being is paramount. One of the most critical aspects of canine health is protecting your furry friend from heartworms. Heartworm disease is a serious and potentially fatal illness caused by parasitic worms transmitted through mosquito bites. Thankfully, there are effective heartworm preventatives available, and we’ve compiled a list of the best heartworm medicine for dogs available on Amazon in 2024. This guide not only reviews each product but also provides insight into what to look for when choosing heartworm medicine.
- Dewormer for Dogs: PetArmor 7 Way Chewable De-Wormer for dogs treats and controls 7 species of worms: 2 types of tapeworms, 2 types of roundworms, and 3 types of hookworms
- Vet Quality: These vet-quality tablets are safe for puppies 12 weeks or older, and large dogs 25.1 to 200 lbs
- Dewormer Tablets: PetArmor broad spectrum dewormer comes in chewable tablets, making it easy and convenient to give to your dog
- How to Use: Watch your dog for a few minutes after dosing to make sure the chewable dog dewomer is not rejected and the full dose of dewormer is eaten
- Recommended Use: For best results with any PetArmor dog dewormer read and follow label intructions. If you need to retreat your dog, we recommend consulting with your veterinarian and have them perform a fecal test to rule out any other issues or parasites
- Interceptor PLUS protects against more types of worms than other formulas
- Tasty, monthly chewable is flavored with real chicken, making dosing easy
- Prevents heartworm disease plus treats and controls adult hookworm, roundworm, whipworm and tapeworm infections
- Covers worms commonly found in dog parks trails, backyards or carried by mosquitoes
- Delivers 30 days of protection
- Vet-recommended heartworm preventive
- Effectively prevents heartworm disease
- Also treats and controls roundworms & hookworms
- From the brand trusted over 2.5 billion times
- Delicious once a month real-beef chew that dogs love
- Vet-recommended heartworm preventive
- Effectively prevents heartworm disease
- Also treats and controls roundworms & hookworms
- From the brand trusted over 2.5 billion times⁵
- Delicious once a month real-beef chew that dogs love⁶
- Easy and convenient Chewable
- Available without a prescription
- Treats and controls seven strains of tape Hook and roundworms
- Non prescription
- Prevents heartworm disease, treats, and controls roundworms and hookworms
- Kills heartworm larvae before they reach your dog’s heart
- Enjoy year-round protection for your dog, with monthly treatments
- Easy-to-give, beef-flavored, chewable tablet that your dog will enjoy.
- Safe for dogs with beef allergies
- Convenient 12 Pack
- Non prescription
- Controls seven strains of tape; hook and roundworms
- Chewable Tablets ; Packaging may vary
- Feeding directions - 25.1 to 50.0 pounds, give 1 Medium/Large Dog(114mg) tablet . 50.1 to 100.0 pounds, give 2 Medium/Large Dog(114mg) tablets. 100.1 to 150.0 pounds, give 3 Medium/Large Dog(114mg) tablets. 150.1 to 200.0 pounds, give 4 Medium/Large Dog(114mg) tablets
- BROAD SPECTRUM: This dog dewormer treats and controls two types of tapeworms, two types of roundworms, and three types of hookworms.
- OVER-THE-COUNTER WORM MEDICINE FOR DOGS: SENTRY HC WORM X PLUS 7 Way De-Wormer contains two active ingredients found in veterinary brands: pyrantel pamoate and praziquantel and is available without a prescription.
- EASY TO USE: These tasty chewable SENTRY DeWormer tablets can be given to your dog with or without food.chewable tablets are easy to use and can be given to your dog with or without food.
- These tasty chewable tablets are easy to use and can be given to your dog with or without food. For medium to large dogs, 12 weeks and older, weighing over 25 pounds.
- TREAT REGULARLY: Utilize subscribe and save to regularly treat your pet against all three types of hookworms.
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
- Easy-to-give beef-flavored chewable tablet
- Broad-spectrum dewormer
- Effective against tapeworms, roundworms, hookworms and whipworms
- For use in dogs over 4 weeks of age
- Warning: Keep out of reach of children
Why Heartworm Prevention is Important
Heartworms can grow up to a foot long and live within a dog’s heart and lungs, leading to severe health complications. Recognizing the importance of preventive care is essential to ensure your pet remains healthy and happy. Heartworm medicine can effectively prevent infection, making it a must-have in every dog owner’s arsenal.
Buying Guide for Heartworm Medicine for Dogs
When selecting heartworm medicine for your dog, consider the following factors:
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Age and Weight: Different products cater to varying weight categories and age groups, so ensure you choose one that fits your dog’s profile.
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Type of Medication: Medications can vary from oral tablets to topical treatments and injections. Choose what’s most manageable for you and your dog.
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Monthly vs. Annual Administration: Some medications require monthly doses while others might provide longer-lasting effects. Consider your convenience and your dog’s needs.
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Vet Recommendation: Always consult your veterinarian before starting any heartworm medication to get guidance tailored to your pet’s specific health requirements.
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Active Ingredients: Research the ingredients to understand how they work and any potential side effects.
- User Reviews: Check customer feedback to glean insights from other pet owners about effectiveness and potential issues.
With this guide in mind, let’s take a closer look at the top 10 heartworm medicines available on Amazon.
Top 10 Heartworm Medicines for Dogs
1. Heartgard Plus Chewables
Heartgard Plus Chewables are a popular choice among dog owners. These monthly chewable tablets are designed to prevent heartworm disease while treating and controlling roundworms and hookworms. They are beef-flavored, making them highly palatable for dogs.
The active ingredients, Ivermectin and Pyrantel, work synergistically to eliminate common intestinal parasites. Heartgard Plus is suitable for dogs of all ages, and its effectiveness has made it a veterinarian favorite.
- Vet-recommended heartworm preventive
- Effectively prevents heartworm disease
- Also treats and controls roundworms & hookworms
- From the brand trusted over 2.5 billion times⁵
- Delicious once a month real-beef chew that dogs love⁶
2. Interceptor Plus
Interceptor Plus is a chewable tablet that protects against heartworms and also treats common intestinal worms. It has a beef flavor that dogs love, ensuring ease of administration. The active ingredients—Milbemycin oxime and Praziquantel—offer broad-spectrum protection.
This product is ideal for dogs of all sizes and can be used in puppies as young as 6 weeks. Interceptor Plus is well-regarded for its efficacy and safety.
- Interceptor PLUS protects against more types of worms than other formulas
- Tasty, monthly chewable is flavored with real chicken, making dosing easy
- Prevents heartworm disease plus treats and controls adult hookworm, roundworm, whipworm and tapeworm infections
- Covers worms commonly found in dog parks trails, backyards or carried by mosquitoes
- Delivers 30 days of protection
3. Revolution for Dogs
Revolution is a topical solution that not only prevents heartworms but also protects against fleas, ticks, and certain types of mites. This monthly treatment is easy to apply and quickly absorbs into the skin.
The active ingredient, Selamectin, is effective for dogs over 6 weeks old. Revolution’s comprehensive protection makes it a preferred choice for dog owners who want an all-in-one solution.
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
4. Advantage Multi for Dogs
Advantage Multi is a topical solution that prevents heartworm disease while also controlling fleas, roundworms, hookworms, and whipworms. It features the active ingredient, Imidacloprid, coupled with Moxidectin, which is effective against heartworms.
This product is suitable for dogs over 7 weeks old, making it an effective preventive option. Dog owners appreciate its versatility in protecting against multiple infestations.
- K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
- Kills fleas within 12 hours of application
- Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
- Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
- No prescription needed
5. ProHeart 12
ProHeart 12 is an injectable heartworm prevention given once a year. This product offers a long-lasting effect and is convenient for busy dog owners who may forget monthly administration.
The active ingredient is Moxidectin, providing effective protection against heartworms. ProHeart 12 is suitable for dogs 12 weeks and older, making it a fantastic option for those seeking long-term protection.
- REPELS - AN ADDED LAYER OF PROTECTION. Using natural essential oils, this dog collar offers an added layer of repellency against fleas and ticks for up to 4 months and mosquitoes for up to 1 month. Helps prevent flea and tick infestations. Pair collar with our Flea and Tick Spray for Pets and Home for maximum layered protection.
- TREAT NATURE WITH NATURE. Replaces chewable flea and tick protection and conventional spot drops and collars. Powered by plants, this collar is safe and effective at repelling fleas and ticks for dogs and puppies over 4 months when used as directed. Enjoy peace of mind knowing your pets are protected.
- FOR DOGS 4+ MONTHS. This collar is easy to cut-to-size for dogs and can be used on most pet sizes. Fits up to 21” neck. Natural essential oils make it a safe alternative to traditional spot drops and collars. Safe to use around kids when used as directed. Mom owned, Mom approved.
- WATER RESISTANT WITH FRESH PEPPERMINT SCENT. With steam distilled essential oil of peppermint, this plant powered repellent smells great. No artificial fragrance. Collar is water resistant and can be worn during normal pet bath time or occasional swims.
- POWERFULLY EFFECTIVE. Powered by nature and proven to work. Give your dog the best advantage in protection against fleas and ticks with our non-harsh formula. Cruelty free, made in the U.S.A. with sustainable ingredients and recyclable packaging.
6. Sentinel Spectrum
Sentinel Spectrum is a monthly chewable that not only prevents heartworms but also treats and controls fleas and intestinal worms. It has tasty flavors and is formulated for dogs of different sizes.
The combination of Lufenuron, Milbemycin oxime, and Praziquantel provides comprehensive protection. This product is suitable for dogs from 2 pounds, making it a versatile choice for small breeds.
- Protects against 6 different types of parasites, including tapeworms.
- Unique to SENTINEL brand products, lufenuron stops flea eggs from hatching.¹
- Protects against heartworms, tapeworms, hookworms, roundworms, and whipworms.¹
- SENTINEL SPECTRUM does all this with convenient and effective once-a-month dosing and a soft beef and bacon-flavor dogs love.²,³
- ¹SENTINEL SPECTRUM Chews [prescribing information]. Madison, NJ: Merck Animal Health; 2020. ²Data on file. Merck Animal Health. ³SENTINEL SPECTRUM CHEWS [Freedom of Information] NADA #141-333.
7. Comfortis
Comfortis is primarily known for its flea prevention and treatment but also has some formulations that assist in heartworm prevention. This oral tablet works quickly to eliminate fleas and is easy to administer due to its beef flavor.
While not a standalone heartworm preventative, it’s often used in conjunction with heartworm medications for comprehensive protection against parasites.
- A chewable, beef-flavored tablet that kills fleas and prevents and treats infestations on dogs and cats for a full month.
- A fast, safe and effective treatment for flea infestations.
- The first FDA-approved tablet that kills fleas and prevents flea infestations for a full month.
- Convenient to give and mess-free.
- Fast: Starts killing fleas in 30 minutes–before they can lay eggs
8. Trifexis
Trifexis is another oral chewable that combines flea prevention (Spinosad) with heartworm prevention (Milbemycin oxime) and also treats hookworms, roundworms, and whipworms.
This product is suitable for dogs over 8 weeks old and has a beef flavor that dogs love, making it a seamless addition to your dog’s routine.
- Fast-Acting Flea Treatment: Capstar (nitenpyram) starts eliminating adult fleas in just 30 minutes
- Tackle Flea Infestations Fast: With one dose of CAPSTAR, you can watch the dead fleas fall off your pet
- Treat Reinfestations Fast: If your pet gets reinfested with fleas, simply give another dose as often as once a day
- No Prescription Needed: Fast, effective flea treatment that's available over the counter
- Intended Use: Capstar Oral Flea Treatment for Large Dogs (57 mg) is safe for dogs and puppies 4 weeks and older that weigh 25.1-125 pounds
9. K9 Advantix II
K9 Advantix II is a topical solution that repels and kills fleas, ticks, and mosquitoes, preventing heartworm transmission. This powerful formula is fast-acting and lasts for up to 30 days.
While not primarily a heartworm preventative, its ability to repel mosquitoes can be a crucial part of comprehensive heartworm prevention. Suitable for dogs 7 weeks and older, K9 Advantix II is safe and effective.
- K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
- Kills fleas within 12 hours of application
- Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
- Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
- No prescription needed
10. Vet’s Best Heartworm Preventative
Vet’s Best offers a natural approach to heartworm prevention with a formulation of traditional ingredients that help keep mosquitoes at bay. This product can be used as an aid alongside other heartworm treatments.
While it may not be a standalone solution, it supports mosquito bite prevention, reducing the risk of heartworm transmission effectively.
- Vet-recommended heartworm preventive
- Effectively prevents heartworm disease
- Also treats and controls roundworms & hookworms
- From the brand trusted over 2.5 billion times
- Delicious once a month real-beef chew that dogs love
Conclusion
Choosing the best heartworm medicine for dogs is essential for maintaining their health and well-being. From chewable tablets to topical solutions, there are numerous options available on Amazon, catering to various needs and preferences. Always consult with your veterinarian to determine which product best fits your dog’s specific health requirements.
By prioritizing preventive care, you can keep your furry friend safe from heartworm disease, giving you peace of mind and a happy, healthy companion for years to come.
- Dewormer for Dogs: PetArmor 7 Way Chewable De-Wormer for dogs treats and controls 7 species of worms: 2 types of tapeworms, 2 types of roundworms, and 3 types of hookworms
- Vet Quality: These vet-quality tablets are safe for puppies 12 weeks or older, and large dogs 25.1 to 200 lbs
- Dewormer Tablets: PetArmor broad spectrum dewormer comes in chewable tablets, making it easy and convenient to give to your dog
- How to Use: Watch your dog for a few minutes after dosing to make sure the chewable dog dewomer is not rejected and the full dose of dewormer is eaten
- Recommended Use: For best results with any PetArmor dog dewormer read and follow label intructions. If you need to retreat your dog, we recommend consulting with your veterinarian and have them perform a fecal test to rule out any other issues or parasites
- Interceptor PLUS protects against more types of worms than other formulas
- Tasty, monthly chewable is flavored with real chicken, making dosing easy
- Prevents heartworm disease plus treats and controls adult hookworm, roundworm, whipworm and tapeworm infections
- Covers worms commonly found in dog parks trails, backyards or carried by mosquitoes
- Delivers 30 days of protection
- Vet-recommended heartworm preventive
- Effectively prevents heartworm disease
- Also treats and controls roundworms & hookworms
- From the brand trusted over 2.5 billion times
- Delicious once a month real-beef chew that dogs love
- Vet-recommended heartworm preventive
- Effectively prevents heartworm disease
- Also treats and controls roundworms & hookworms
- From the brand trusted over 2.5 billion times⁵
- Delicious once a month real-beef chew that dogs love⁶
- Easy and convenient Chewable
- Available without a prescription
- Treats and controls seven strains of tape Hook and roundworms
- Non prescription
- Prevents heartworm disease, treats, and controls roundworms and hookworms
- Kills heartworm larvae before they reach your dog’s heart
- Enjoy year-round protection for your dog, with monthly treatments
- Easy-to-give, beef-flavored, chewable tablet that your dog will enjoy.
- Safe for dogs with beef allergies
- Convenient 12 Pack
- Non prescription
- Controls seven strains of tape; hook and roundworms
- Chewable Tablets ; Packaging may vary
- Feeding directions - 25.1 to 50.0 pounds, give 1 Medium/Large Dog(114mg) tablet . 50.1 to 100.0 pounds, give 2 Medium/Large Dog(114mg) tablets. 100.1 to 150.0 pounds, give 3 Medium/Large Dog(114mg) tablets. 150.1 to 200.0 pounds, give 4 Medium/Large Dog(114mg) tablets
- BROAD SPECTRUM: This dog dewormer treats and controls two types of tapeworms, two types of roundworms, and three types of hookworms.
- OVER-THE-COUNTER WORM MEDICINE FOR DOGS: SENTRY HC WORM X PLUS 7 Way De-Wormer contains two active ingredients found in veterinary brands: pyrantel pamoate and praziquantel and is available without a prescription.
- EASY TO USE: These tasty chewable SENTRY DeWormer tablets can be given to your dog with or without food.chewable tablets are easy to use and can be given to your dog with or without food.
- These tasty chewable tablets are easy to use and can be given to your dog with or without food. For medium to large dogs, 12 weeks and older, weighing over 25 pounds.
- TREAT REGULARLY: Utilize subscribe and save to regularly treat your pet against all three types of hookworms.
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
- Easy-to-give beef-flavored chewable tablet
- Broad-spectrum dewormer
- Effective against tapeworms, roundworms, hookworms and whipworms
- For use in dogs over 4 weeks of age
- Warning: Keep out of reach of children
Last update on 2025-07-01 / Affiliate links / Images from Amazon Product Advertising API | hishecozy.com is a participant in the Amazon Associate program and will earn from qualifying purchases.