Best Enzyme Powder: Top Products for 2025 You Need to Try

In 2025, enzyme powders have gained significant popularity for their potential health benefits. They are often marketed for digestive support, improved gut health, and even enzyme supplementation for various biological functions. This article delves into the top 10 enzyme powders available on Amazon, reviewing their features and benefits, while helping you decide which is the best enzyme powder for your needs. You’ll also find a comprehensive buying guide at the end to simplify your purchasing decision.

1. Garden of Life RAW Enzymes for Men

Garden of Life’s RAW Enzymes for Men is specifically formulated to meet the unique digestive needs of men. With a blend of over 70 whole food enzymes, this product aims to enhance digestion and nutrient absorption effectively.

The powder is vegan, dairy-free, and gluten-free, making it suitable for various dietary restrictions. Many users have reported an improvement in their digestion after incorporating this enzyme powder into their daily regimen. The added probiotics further enhance gut health, making this a great option for those seeking holistic support.

Pros:
– Contains 70+ enzymes
– Vegan and gluten-free
– Includes probiotics for gut health

Cons:
– Slightly more expensive than competitors
– Some may find the taste not to their liking

Bestseller No. 1
Garden of Life 22 Digestive Enzymes for Men with Bromelain, Papain & Lactase Plus Probiotics & Whole Food Vitamins B12, Biotin & Zinc – RAW Enzymes – Non-GMO, Gluten-Free, Vegetarian, 90 Capsules
  • MADE FOR HIM: Young active men need higher protein intakes to meet their bodies’ demands; RAW Men has been formulated to meet the unique digestive and overall health needs of men by focusing on fat and protein-digesting enzymes so that he can stay strong
  • THE RAW STANDARD: Raw is uncooked food in its natural state and prepared without heat; RAW Enzymes is untreated, uncooked and unaltered to preserve the high activity levels of essential enzymes so that your body can break down and absorb its nutrients
  • DON’T TAKE THE HEAT: Our formula has 22 digestive enzymes, probiotics, probiotic-created vitamins and minerals and antioxidant enzymes to help process difficult-to-digest foods and support colon and prostate health, gut-related immunity and digestion
  • RULE OF THUMB: RAW Men is the most complete digestive enzyme formula available because when we transform our raw materials, we do not ever heat them above 115 degrees; Temperatures above 115 could kill enzymes and deplete vitamins and minerals we need
  • EMPOWERING EXTRAORDINARY HEALTH: Our digestive enzyme supplement is made to empower you with extraordinary health and is Third-Party Certified Non-GMO and NSF Gluten-Free; Made without dairy, peanut or tree nut ingredients

2. Zenwise Health Digestive Enzymes

Zenwise Health Digestive Enzymes contain a potent blend of 15 natural enzymes designed to support digestion and ease bloating. This powder is particularly popular among individuals who struggle with lactose intolerance, thanks to its lactase content.

Users appreciate the convenience of this enzyme powder, which can be added easily to smoothies or meals. The overall feedback indicates significant improvements in digestion, especially after heavy meals. At an affordable price point, this product is a great choice for anyone wanting to enhance their digestive prowess.

Pros:
– Contains lactase for lactose digestion
– Affordable
– Easy to mix in food or drinks

Cons:
– Some users may require a higher dose for maximum effect
– Taste can be slightly off

OFF -$10.00Bestseller No. 1
Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 180 Count
  • 3-in-1 Formula – Blend of lab proven enzymes, clinically proven probiotics and prebiotics works synergistically to break down proteins, fats, and carbs while resorting digestive flora balance for optimal nutrient absorption and digestion maintain digestive wellness and promote regularity
  • Fast-Acting Enzymes – Powerful enzyme blend starts working immediately to break down food up to 39% more completely, and ease indigestion for rapid, noticeable relief
  • Proven Probiotics – Guaranteed to arrive alive and work within hours in the small intestine where 90% of nutrient absorption occurs
  • Gas & Bloating Relief - Targeted enzymes work with beneficial microflora to ease uncomfortable bloating, reduce gas, and soothe digestive discomfort naturally
  • Plant-Based Formula - Pure vegetarian enzymes combined with prebiotic fiber nourish your microbiome while supporting healthy digestion and immune function – take 1 capsule before your meal to experience digestive delight

3. NOW Foods Super Enzymes

NOW Foods Super Enzymes combines a potent blend of enzymes for comprehensive digestive support. This product is well-known for its ability to break down fats, proteins, and carbs effectively.

Along with digestive enzymes, this powder also contains bromelain and ox bile, which contribute to smoother digestion. Users have reported that this product not only enhances their digestion but also helps in reducing bloating and discomfort post-meals. Its reputation for quality and effectiveness has made it one of the best enzyme powders on Amazon.

Pros:
– Comprehensive blend of enzymes
– Reduces bloating effectively
– High-quality ingredients

Cons:
– Contains ox bile, which may not be suitable for everyone
– Some may find it overpowering

OFF -$2.33Bestseller No. 1
NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules
  • SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal
  • BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein*
  • CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
  • Packaged in the USA by a family owned and operated company since 1968

4. Garden of Life RAW Enzymes for Women

Similar to its counterpart for men, Garden of Life RAW Enzymes for Women is specially formulated for female digestive health. With a carefully selected blend of enzymes, this product aids digestion and promotes gut health.

This product also contains probiotics and prebiotics, providing comprehensive digestive support. Users have reported favorable results in terms of ease of digestion and overall gut health improvement. This enzyme powder is dairy-free and vegan, catering to various dietary preferences.

Pros:
– Tailored for women’s digestive needs
– Includes probiotics and prebiotics
– Vegan and dairy-free

Cons:
– Higher price point
– May not suit everyone’s taste

OFF -$13.22Bestseller No. 1
Garden of Life 22 Digestive Enzymes for Women with Bromelain, Papain, Lipase & Lactase plus Probiotics & Vitamins B12, Biotin & Zinc – RAW Enzymes – Non-GMO, Gluten-Free, Vegetarian, 90 capsules
  • MADE FOR HER: RAW Enzymes is designed to support your nutritional and digestive needs no matter what stage of life you are in; RAW Women is formulated for the digestive and overall health needs of women with amplified potencies of carb digesting enzymes
  • THE RAW STANDARD: Raw is uncooked food in its natural state and prepared without heat; RAW Enzymes is untreated, uncooked and unaltered to preserve the high activity levels of essential enzymes so that your body can break down and absorb its nutrients
  • DON’T TAKE THE HEAT: Our formula has 22 digestive enzymes, probiotics, probiotic-created vitamins and minerals and antioxidant enzymes to help process difficult-to-digest food and support colon, bone and breast health, gut-related immunity and digestion
  • RULE OF THUMB: RAW Women is the digestive enzyme formula you can count on because when we transform our raw materials, we do not ever heat them above 115 degrees; Temperatures above 115 could kill enzymes and deplete vitamins and minerals we need
  • EMPOWERING EXTRAORDINARY HEALTH: Our digestive enzyme supplement is made to empower extraordinary health and is Third-Party Non-GMO Project Verified, Certified Gluten-Free and Vegetarian; Made in the USA with no dairy, soy, gluten or nuts

5. MaryRuth Organics Digestive Enzymes

MaryRuth Organics offers an enzyme powder that is made with 100% organic ingredients. This product is specifically designed to promote digestive health and nutrient absorption.

What sets this enzyme powder apart is its sugar-free and gluten-free formulation. Many users have praised its efficacy in alleviating digestive discomfort, particularly after heavy meals. The organic nature of the ingredients provides an extra layer of appeal for health-conscious consumers.

Pros:
– 100% organic ingredients
– Sugar-free and gluten-free
– Effective in reducing digestive discomfort

Cons:
– More expensive than some alternatives
– Limited availability in certain regions

OFF -$5.39Bestseller No. 1
MaryRuth Organics Gut Flora Health+ Enzymes | Up to 2 Month Supply | Prebiotic Probiotic Digestive Enzymes Blend for Healthy Gut Biome & Digestive Support | Gastrointestinal Health | 60 Capsules
  • Gut Flora Health+ Enzymes: The gut’s microbiome plays a significant role in overall health! This robust prebiotic, probiotic and enzyme blend is formulated to support gastrointestinal health and maintain a healthy gut environment. Encapsulated in pine-based vegan capsules, you can easily incorporate these into your routine.
  • Multiple Benefits: Enzymes support digestion and probiotics support a healthy microbiome. Enjoy a proprietary enzyme blend of Protease, Cellulase, Chitosanase, and Serrapeptase enzymes.
  • Proprietary Probiotic Blend: Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus plantarum, Lactobacillus salivarius, Lactobacillus casei, Lactobacillus brevis, Streptococcus thermophiles, Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Saccharomyces boulardii, Bacillus coagulant
  • Prebiotic Probiotic & Enzyme Complex: Adults take 1 capsule, up to 2 times daily or as recommended by a physician or healthcare professional. For best results, take on an empty stomach with a large glass of water, once in the morning and once in the evening, either 30 minutes before or 2 hours after a meal.
  • For Most Lifestyles: MaryRuth's Gut Flora Enzymes are Non-GMO & Vegan. Dairy Free, Nut Free, Gluten Free, Sugar Free. This product Contains Maltodextrin: which is corn-derived. Each bottle comes with 30-60 servings. Store in a cool, dry place. B Corp Certified.

6. Source Naturals Daily Essential Enzymes

Source Naturals Daily Essential Enzymes provide a comprehensive combination of enzymes to aid in the digestion of fats, carbohydrates, and proteins. This powder is designed to improve digestive efficiency for optimal nutrient absorption.

Users have reported improved digestive health and relief from discomfort associated with heavy meals. It’s a cost-effective solution for those looking for a robust enzyme blend. The powder is easy to mix with water or juice, making it convenient for daily use.

Pros:
– Comprehensive digestive support
– Easy to mix
– Economical

Cons:
– Some users may find it less effective than premium options
– Not suitable for those allergic to certain ingredients

OFF -$4.52Bestseller No. 1
Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Supplement Herbal Defense for Digestion, Gas & Constipation Relief - Strong Immune System Support* - 120 Capsules
  • ESSENTIAL ENZYMES BENEFITS. Expertly formulated compilation of digestive enzymes that break down multiple food groups: carbohydrates, protein, fat and fiber.
  • HOW ESSENTIAL ENZYMES WORK. It aids the body’s natural digestive process and helps maximize the body’s utilization of the nutrients in the diet by helping to break down foods into smaller components that can be absorbed
  • SUGGESTED USE: 1 capsule with water at the beginning of each meal (or open capsule and sprinkle over food). Do not sprinkle on hot food. Do not exceed 6 capsules per day.
  • OVER 40 YEARS OF TRUST. Source Naturals was created in 1982 by CEO Ira Goldberg to support each individual's potential to enjoy optimal health.
  • Manufactured in the USA. Manufactured in Scotts Valley, CA, under the Good Manufacturing Practices (cGMPs) established by the US Food and Drug Administration. (FDA)

7. Dr. Tobias Digestive Enzymes

Dr. Tobias Digestive Enzymes offer a potent blend aimed at improving digestive efficiency. The powder includes multiple types of enzymes, each carefully selected for their digestive benefits.

This product has received positive user feedback for its effectiveness in reducing gas and bloating. Many consumers appreciate its ability to allow them to enjoy meals without the fear of digestive discomfort. It’s also gluten-free, making it suitable for various dietary considerations.

Pros:
– Potent blend of enzymes
– Proven effectiveness for gas and bloating
– Gluten-free

Cons:
– May require frequent use to see significant results
– Slightly higher price point

OFF -$5.00Bestseller No. 1
Dr. Tobias Digestive Enzymes with Amylase, Bromelain, Lipase, Lactase, Protease, Papain & More, Digestion Supplement with 18 Enzymes for Digestion and Gut Health, 60 Capsules, 30 Servings
  • Digestive Enzymes Supplement: Our enzyme formula helps with hard to digest food. Each enzyme is specialized to break down specific compounds in proteins, fats, dairy, gluten, and carbs.
  • Essential Enzymes for Enhanced Nutrient Absorption: A comprehensive blend with 18 plant-based enzymes for digestion including Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Invertase, Glucoamylase, & more.
  • Gas and Bloating Relief: Take 1 capsule, 1 to 2 times daily, preferably at the beginning of a meal to help replenish enzymes and minimize digestive discomfort.
  • Premium Quality, Non-GMO: Dr. Tobias digestive enzymes for women and men are made by vitamin experts in a facility that follows GMP (Good Manufacturing Process). Customer satisfaction is our top priority.
  • A Better You Starts Here: Our mission is to encourage people to become the best version of themselves; whether you're looking for a digestive probiotic, gallbladder enzymes, nutrient boost, or colon detox, we have a digestion supplement or daily vitamin to help you get there.

8. Enzymedica Digest Gold

Enzymedica Digest Gold is considered one of the more premium enzyme powders on the market, containing a robust blend of enzymes aimed at optimal digestion. The formulation supports the breakdown of carbohydrates, proteins, and fats.

This enzyme powder is also non-GMO and vegan, making it a suitable option for health-conscious consumers. Users appreciate the fast-acting formula that often alleviates digestive discomfort quickly. This product’s reputation for quality has made it a top choice among consumers looking for the best enzyme powder.

Pros:
– Fast-acting
– Non-GMO and vegan
– Comprehensive blend for optimal digestion

Cons:
– Higher price than many competitors
– Availability may vary

OFF -$5.25Bestseller No. 1
Enzymedica Digest Gold + ATPro, Maximum Strength Digestive Enzymes, Helps Digest Large Meals for Instant Bloating Relief, 45 Count
  • For Food Lovers: Savor your favorite dishes worry-free; Our full-strength, bloat-busting digestive enzyme blend helps break down large meals faster, easing bloating and occasional indigestion for care-free indulgence*
  • ATPro Blend: Beat the post-meal blues and feel fueled with energy to power through your day; This unique formula features ATPro, a proprietary blend of ATP, Magnesium Citrate, Phytase and CoQ10 that helps fuel your body's cells*
  • Effective All the Way Through: Our proprietary Thera-blend enzymes are formulated for optimal activity throughout the digestive system's varying pH levels, providing faster relief and maximum digestive support*
  • Dosage: Just 1 capsule daily breaks down up to 34g fat, 16g protein and 86g carbs; Contains no gluten, milk, casein, soy, egg, artificial colors, flavors, or GMOs; Vegan, Kosher and Clean Label Project Certified
  • Making a Difference: Enzymedica products harness the power of the finest natural ingredients for maximum effectiveness; We create quality products without compromise while championing initiatives that support the well-being of people and our planet

9. Vital Proteins Collagen Peptides with Enzymes

Vital Proteins Collagen Peptides with Enzymes is a unique blend that combines collagen support with digestive enzymes. This dual-action product not only aids in digestion but also promotes skin, joint, and hair health due to its collagen content.

Consumers have expressed satisfaction in both the health benefits and the convenience of being able to combine two supplements into one daily powder. This product is popular among those looking for combined benefits without needing multiple powders.

Pros:
– Dual action for digestion and skin support
– Easy to mix with liquids
– Collagen health benefits

Cons:
– Higher price point due to dual formulation
– Taste may vary depending on mixing

OFF -$8.01Bestseller No. 1
Vital Proteins Collagen Peptides Powder Advanced with Hyaluronic Acid & Vitamin C, 20oz Collagen Protein, Unflavored, 27 Servings
  • SUPPORTS COLLAGEN PRODUCTION: With 100% daily value of Vitamin C, this Vital Proteins Collagen Peptides Advanced Powder helps promote collagen production which is important for maintaining healthy skin
  • SUPPLE SKIN HYDRATION: Contains 120mg Hyaluronic Acid to support skin hydration and collagen for skin elasticity
  • HIGHLY BIOAVAILABLE: Derived from grass-fed, pasture-raised bovine, our hydrolyzed collagen peptides are easily digested and absorbed by the body
  • VERSATILE AND EASY TO USE: Dissolve one serving of Vital Proteins collagen daily in hot or cold beverages like coffee, tea, or smoothies for a convenient collagen boost
  • QUALITY INGREDIENTS: Paleo Friendly and Whole30 Approved, our collagen supplements are made without dairy and gluten

10. Hydroxycut Pro Clinical Appetite Control Enzyme Powder

Hydroxycut Pro Clinical offers an enzyme powder designed not only to aid digestion but also to help control appetite. This product is excellent for individuals seeking weight management support along with digestive health.

Users have reported feeling less bloated and more satisfied post-meals, indicating that it effectively curbs cravings. However, due to its unique formulation, it may be more suitable for those already engaged in weight management protocols.

Pros:
– Dual benefit for digestion and appetite control
– Effective in reducing bloating
– Convenient powder format

Cons:
– May not suit those not focused on weight management
– Some users reported mild side effects

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Buying Guide for Enzyme Powder

When choosing the best enzyme powder, it’s crucial to consider several key factors to ensure you’re getting a product that meets your specific needs. Here are some essential aspects to keep in mind:

Ingredients

Look for enzyme powders that list their ingredients clearly. A good product should contain a range of enzymes (such as protease, lipase, and amylase) that support the digestion of various macronutrients. Additionally, check for the presence of probiotics and prebiotics, which enhance gut health.

Formulation

Different enzyme formulas cater to different needs. If you have a particular digestive concern, such as lactose intolerance, select enzyme powders that specifically address that issue. For those simply looking for general digestive support, a broad-spectrum enzyme product may suffice.

Quality and Safety

Opt for reputable brands that adhere to safety and quality standards. Look for certification seals such as Non-GMO, gluten-free, and vegan if these are pertinent to your dietary needs.

Flavor and Mixability

The flavor of the enzyme powder is crucial, especially if you’re planning to mix it into drinks or foods. Some powders are unflavored, while others may come with added flavors—check for this based on your preference. Additionally, ensure the powder is easily mixable without clumping.

Price

While price shouldn’t be the sole deciding factor, it’s essential to find a product that offers good value for money. Check quantity versus price to determine the best option for your budget.

Customer Reviews

Lastly, always check customer reviews for insights into the product’s effectiveness and any potential issues others have experienced. This can provide valuable information before making a purchase.

In conclusion, whether you seek improved digestion, digestive comfort, or additional health benefits, enzyme powders are an important supplement to consider in 2025. Evaluate the highlighted enzyme powder options on Amazon with the standards discussed to help you find the best enzyme powder for your needs.

Last update on 2025-12-26 / Affiliate links / Images from Amazon Product Advertising API | hishecozy.com is a participant in the Amazon Associate program and will earn from qualifying purchases.

Evelyn Hawthorne
Evelyn Hawthorne