Finding the best bed bug spray can be a daunting task, especially as infestations become increasingly prevalent. Luckily, Amazon offers a plethora of options designed to help you combat these pesky intruders. In this article, we will explore the best bed bug spray available on Amazon, providing an in-depth review of the top 10 products for 2025 that promise to eliminate bed bugs effectively. Let’s get started!
- Kill bed bugs, bed bug eggs, fleas and ticks with Ortho Home Defense Max Bed Bug, Flea & Tick Killer
- This bed bug spray kills even the toughest bed bugs (pyrethroid-resistant bed bugs)
- Use this indoor bug killer as a spot treatment around bed frames, baseboards and mattress seams, tufts and folds
- Apply insect spray using the included Comfort Wand to target tight and hard-to-reach places where bed bugs hide
- Ortho Home Defense Max Bed Bug, Flea & Tick Killer is a Step 2 product in the Ortho Bed Bug Solution System; use with Step 1: Detect and Trap and Step 3: Cracks and Crevices products for best results
- PATENTED FORMULA: CrossFire bed bug spray kills pyrethroid-resistant bed bug strains at all life stages, including eggs. With its two active ingredients and a synergist, get effective bed bug control.
- QUICK KNOCKDOWN AND KILL: Begins working within minutes of exposure. This professional product is backed by multiple active ingredients.
- NON-STAINING: For indoor use in residential, institutional and commercial facilities, this bed bugs killer treatment is approved for direct application onto mattresses.
- EASY TO MIX AND USE: One 13-ounce bottle of bed bug concentrate makes one gallon of finished product.
- A LEGACY YOU CAN TRUST: Driven by expertise and industry commitment, MGK has been developing pest control products based primarily on botanical and innovative technologies since 1902.
- Tough Formula: Formulated for maximum strength, this Black Label bed bug spray is a powerful solution, designed to kill even the most persistent and pesticide-resistant bed bugs.
- Kills Bed Bugs, Eggs, and Pyrethroid-Resistant Strains: Effectively eliminates all life stages of bed bugs, including hard-to-kill eggs and resistant strains that survive standard treatments.
- Long-Lasting Residual Protection: Provides extended control for up to 16 weeks after application, making it ideal for long-term bed bug management and prevention.
- EPA Registered for Indoor Use: Registered with the EPA (Reg. No. 1021-2597-3) for safe use in homes, apartments, hotels, and other residential environments. Use as directed.
- Complete Home Coverage: Designed for use in bedrooms, living spaces, baseboards, cracks, and crevices to target bed bug hiding spots throughout the entire home.
- BED BUG TREATMENT: Hot Shot Bed Bug Killer With Egg Kill kills bed bugs and bed bug eggs, adult and pre-adult (larvae) fleas and dust mites.
- USE INDOORS: Spot treat mattress tufts, folds, vent holes, buttons, creases, indentations and seams – do not use on pets.
- WATER-BASED FORMULA: This non-staining formula leaves no odor.
- APPLICATION: Spray intended use areas until damp, but do not saturate – inspect the area and apply every two weeks while bed bugs are present.
- TREAT BED BUGS AS PART OF A CYCLE: For best results, use this product as part of a comprehensive bed bug treatment plan — treating bed bugs as part of a cycle is key to gaining control.
- Kills bed bugs and their eggs on contact
- Kills bed bugs on surfaces for up to 4 weeks
- Foam expands into hard to reach indoor places, and is easy to see where you sprayed
- Scientifically formulated to kill Pyrethroid-resistant Bed Bug strains
- Money Back Guarantee
- Quick Results: Fast knockdown of bed bugs and fleas, providing fast relief and long-lasting protection; Treat room perimeter at the wall-floor junction; behind, under and inside furniture; on headboards and box springs; mattress edges, tufts, folds, sides and seams; over open carpeted areas and wall coverings; Even treat luggage by directly spraying into pockets, seams, folds and around wheels
- Long-lasting Control: Lasting effectiveness on multiple surfaces for up to 3 weeks; Aids in preventing bed bug hatch; Dual active ingredients target hatching eggs for up to seven months and provides fast knockdown of flea populations
- Reduced Risk Active Ingredient: Dinotefuran, approved for public health use and food handling establishments; Won’t soak carpets or mattresses, dries rapidly and non-staining; Tested and proven to be safe for use in multiple environments
- Easy to Use: The premixed, ready-to-use aerosol spray can be directly used on mattresses and in suspected areas of infestation, making it easy to apply in Apartments, Commercial Structures, Homes, Hotels, Kennels, Motels, and Veterinary Clinics; safe for use around people and pets as instructed; Refer to product label for complete list; Treats up to 2,625 sqft
- Always read, understand and follow label safety and application instructions; For use as intended; State restrictions may applyDO NOT apply to entire mattress; apply only to edges, tufts, folds, sides and seams
- Bed bug exterminator: Our natural bed bug killer spray is for home DIY or Our formula eradicates bugs & pests on contact. Originally for pest control pros, the travel spray is now available to the public.
- Odorless & stain-free: Hygea Natural's unique formula can be used on any surface including upholstery, mattresses, bed linens, clothing, floors, walls, etc. Spray a light mist of the portable bed bug spray. It won’t leave a residue.
- Child & Pet friendly : The Formula powerfully exterminates bed bugs & pests. This bed bug spray is suitable for pets & children. Hygea Natural Exterminator is used by hospitals & hotels nationwide.
- Travel-size bed bug spray: Hygea Natural's bedbug treatment comes in a 3oz spray bottle that is TSA approved for carry on plane travel.
- Step-by-step guide: We provide a 3-step bed bug extermination guide with every purchase. If you do not follow the steps in our guide, we cannot guarantee results.
- FAST-ACTING: Provides quick knockdown and control of bedbugs
- EFFECTIVE FORMULA: Oil-based spray kills bedbugs fast
- VERSATILE USE: Safe for mattresses, baseboards, under furniture, and cushions
- LARGE SIZE: Comes in a convenient gallon size with an additional sprayer
- LEGACY OF TRUST: Since 1932, JT Eaton has been a trusted partner for PMPs worldwide, pioneering solutions like the first paraffin bait block and modern glue board. Today, we continue to lead with innovative products for both the pest control and retail industries.
- HIGHLY EFFECTIVE, NATURAL BED BUG KILLER: EcoVenger Bed Bug Killer uses a patented blend of botanical insecticidal compounds to combat tough insects. A published university study ranks it as the #1 most effective natural product against bed bugs among 12 products tested, outperforming traditional pesticides.
- USDA FIELD-TESTED & PROVEN: Vetted through the USDA IR4 PHP Program and field-tested by research entomologists. Recommended for sensitive environments, it's a trusted solution for eliminating bed bugs in public housing and other vulnerable settings.
- KILLS ALL STAGES, INCLUDING RESISTANT BED BUGS: This formula kills bed bug adults and nymphs on contact with 100% efficacy. It's also proven to eliminate bed bugs resistant to traditional pesticides and has the highest performance in destroying bed bug eggs.
- EXTENDED DRY RESIDUAL PROTECTION: A university study demonstrates that EcoVenger's residual formula provides two weeks of extended protection against bed bugs, even after it has dried, offering long-term peace of mind.
- NON-TOXIC, SAFE & ECO-FRIENDLY: Certified as a USDA BioBased insecticide and dermatologically safe. This product is child and pet-friendly, making it safe to use directly on mattresses and box springs without worry.
- 5 Minute Kill Time – Kills bed bugs at all life stages in 5 minutes after direct contact
- Patent Pending Technology – Uses metofluthrin, clothianidin and piperonyl butoxide
- Residual Kill – The EPA claim for the residual of the product is 1 month
- EPA Registered – Registered with the Environmental Protection Agency (No. 1021-2793-3) for use in homes
- Harris Exclusive – Harris has an exclusive on this formula in the retail market
Buying Guide for the Best Bed Bug Spray
Before diving into product reviews, it’s essential to understand what makes a bed bug spray effective. Here are some key factors to consider when making your choice:
Active Ingredients
Look for sprays with proven active ingredients. Common ones include pyrethroids, neonicotinoids, and diatomaceous earth. Each ingredient targets bed bugs differently, so research their effectiveness before purchasing.
Safety
Ensure the product is safe for your family and pets. Non-toxic options are preferable, especially if you have children or animals in your home. Always read labels and user reviews regarding safety concerns.
Ease of Use
Consider how easy the spray is to apply. Some come with special nozzles for targeted treatment, while others might require more effort. Choose a spray that fits your comfort level and needs.
Durability
Some sprays offer long-lasting protection, while others may require multiple applications. If you’re dealing with a severe infestation, a product with residual effects might be the better choice.
Price
While the effectiveness should be your primary concern, budget is also important. Compare prices and quantities to find the best value without sacrificing quality.
Top 10 Bed Bug Sprays on Amazon for 2025
1. EcoSMART Organic Bed Bug Killer
EcoSMART’s Organic Bed Bug Killer is a popular choice for environmentally conscious consumers. This spray is made from plant-based ingredients, providing a non-toxic solution to pesky bed bugs.
The product is designed to kill on contact, targeting bed bugs at all life stages. Users appreciate the pleasant smell compared to traditional insecticides, making it a more enjoyable application process.
While it’s a great option for light infestations, some users report that it may require multiple applications for severe cases.
- HIGHLY EFFECTIVE, PLANT-POWERED BED BUG KILLER: EcoVenger Bed Bug Killer uses a patented blend of botanical insecticidal compounds to combat tough insects. A published university study ranks it as the #1 most effective natural product against bed bugs among 12 products tested, outperforming traditional pesticides.
- USDA FIELD-TESTED & PROVEN: Vetted through the USDA IR4 PHP Program and field-tested by research entomologists. Recommended for sensitive environments, it's a trusted solution for eliminating bed bugs in public housing and other vulnerable settings.
- KILLS ALL STAGES, INCLUDING RESISTANT BED BUGS: This formula kills bed bug adults and nymphs on contact with 100% efficacy. It's also proven to eliminate bed bugs resistant to traditional pesticides and has the highest performance in destroying bed bug eggs.
- EXTENDED DRY RESIDUAL PROTECTION: A university study demonstrates that EcoVenger's residual formula provides two weeks of extended protection against bed bugs, even after it has dried, offering long-term peace of mind.
- NON-TOXIC, SAFE & ECO-FRIENDLY: Certified as a USDA BioBased insecticide and dermatologically safe. This product is child and pet-friendly, making it safe to use directly on mattresses and box springs without worry.
2. Harris Bed Bug Killer
Harris Bed Bug Killer is a highly rated product known for its effectiveness against bed bugs. This spray contains the powerful active ingredient pyrethroid, which is known to eradicate bed bugs on contact.
One of its standout features is the integrated wand that allows for precise application in cracks and crevices where bed bugs tend to hide. It also offers a residual effect, meaning it continues to kill bed bugs after the initial application.
However, it’s worth noting that users should follow the instructions closely to ensure effectiveness and safety.
- Kills Resistant Bed Bugs & Their Eggs - Kills even the toughest "pyrethroid resistant" bed bugs and eggs that have built up a resistance to traditional pesticides
- Kills Quickly - Knocks down bed bugs fast when sprayed directly
- EPA Registered - Approved for use in homes with people and pets by the Environmental Protection Agency. Always follow label directions
- Long Residual - Continues to kill bed bugs for up to 16 weeks after initial application
- Variety of Surface Applications - Can be used on mattresses, luggage, furniture, headboards, carpet and much more
3. Bed Bug Blocker Bed Bug Spray
The Bed Bug Blocker Spray is designed to create a protective barrier against bed bugs. This product claims to be both preventive and reactive, killing existing bugs while preventing new infestations.
With its eco-friendly formulation, this spray is safe for use around children and pets, making it a great option for families. It’s easy to apply and dries quickly, which many users appreciate.
Nonetheless, some reviews mention that it may not be as effective for severe infestations, necessitating a more robust solution.
- Kill bed bugs, bed bug eggs, fleas and ticks with Ortho Home Defense Max Bed Bug, Flea & Tick Killer
- This bed bug spray kills even the toughest bed bugs (pyrethroid-resistant bed bugs)
- Use this indoor bug killer as a spot treatment around bed frames, baseboards and mattress seams, tufts and folds
- Apply insect spray using the included Comfort Wand to target tight and hard-to-reach places where bed bugs hide
- Ortho Home Defense Max Bed Bug, Flea & Tick Killer is a Step 2 product in the Ortho Bed Bug Solution System; use with Step 1: Detect and Trap and Step 3: Cracks and Crevices products for best results
4. Hot Shot Bed Bug and Flea Killer
Hot Shot Bed Bug and Flea Killer has gained popularity for its dual-action formula that not only kills bed bugs but also protects against fleas. Its potent formula contains deltamethrin, a highly effective insecticide.
This spray can be used on bedding, carpets, and furniture, making it very versatile. Users note its fast-acting formula and long-lasting protection, which is perfect for ongoing infestations.
On the downside, the strong chemical scent may be off-putting for some users, but the effectiveness tends to outweigh this concern.
- BED BUG TREATMENT: Hot Shot Bed Bug Killer With Egg Kill kills bed bugs and bed bug eggs, adult and pre-adult (larvae) fleas and dust mites.
- USE INDOORS: Spot treat mattress tufts, folds, vent holes, buttons, creases, indentations and seams – do not use on pets.
- WATER-BASED FORMULA: This non-staining formula leaves no odor.
- APPLICATION: Spray intended use areas until damp, but do not saturate – inspect the area and apply every two weeks while bed bugs are present.
- TREAT BED BUGS AS PART OF A CYCLE: For best results, use this product as part of a comprehensive bed bug treatment plan — treating bed bugs as part of a cycle is key to gaining control.
5. Ortho Bed Bug Killer
Ortho is a well-known name in pest control, and their Bed Bug Killer does not disappoint. This product is designed for both indoor and outdoor use, varying application methods from spot treatment to larger area sprays.
The formula provides a quick knockdown effect, and users report that it effectively reaches hidden bugs. Additionally, it’s available in a convenient ready-to-use form.
However, the residual effect is not as strong as some other options, requiring more frequent applications.
- Kill bed bugs, bed bug eggs, fleas and ticks with Ortho Home Defense Max Bed Bug, Flea & Tick Killer
- This bed bug spray kills even the toughest bed bugs (pyrethroid-resistant bed bugs)
- Use this indoor bug killer as a spot treatment around bed frames, baseboards and mattress seams, tufts and folds
- Apply insect spray using the included Comfort Wand to target tight and hard-to-reach places where bed bugs hide
- Ortho Home Defense Max Bed Bug, Flea & Tick Killer is a Step 2 product in the Ortho Bed Bug Solution System; use with Step 1: Detect and Trap and Step 3: Cracks and Crevices products for best results
6. Tazo Bed Bug Killer Spray
Tazo Bed Bug Killer Spray offers an organic blend that’s effective against bed bugs. This product is free from harsh chemicals, making it a safer option for homes with kids and pets.
The formula is designed to kill bed bugs on contact and can also be used as a preventative measure. Users praise its ease of application and pleasant scent, but it may require several applications for full effectiveness.
- Kill bed bugs, bed bug eggs, fleas and ticks with Ortho Home Defense Max Bed Bug, Flea & Tick Killer
- This bed bug spray kills even the toughest bed bugs (pyrethroid-resistant bed bugs)
- Use this indoor bug killer as a spot treatment around bed frames, baseboards and mattress seams, tufts and folds
- Apply insect spray using the included Comfort Wand to target tight and hard-to-reach places where bed bugs hide
- Ortho Home Defense Max Bed Bug, Flea & Tick Killer is a Step 2 product in the Ortho Bed Bug Solution System; use with Step 1: Detect and Trap and Step 3: Cracks and Crevices products for best results
7. Bug Zappers Bed Bug Ultra-Effective Spray
Bug Zappers provides an ultra-effective spray that targets all stages of bed bugs. The formula includes multiple active ingredients that hit bugs hard and keep them from returning.
Users love its versatility, allowing applications on various surfaces. Additionally, the non-toxic nature ensures your family can remain safe while using it.
However, some users found mixed results, indicating that results can vary depending on the severity of the infestation.
- FAST-ACTING: Provides quick knockdown and control of bedbugs
- EFFECTIVE FORMULA: Oil-based spray kills bedbugs fast
- VERSATILE USE: Safe for mattresses, baseboards, under furniture, and cushions
- LARGE SIZE: Comes in a convenient gallon size with an additional sprayer
- LEGACY OF TRUST: Since 1932, JT Eaton has been a trusted partner for PMPs worldwide, pioneering solutions like the first paraffin bait block and modern glue board. Today, we continue to lead with innovative products for both the pest control and retail industries.
8. EcoSMART Bed Bug & Flea Killer
Another standout option from EcoSMART, this Bed Bug & Flea Killer is crafted with plant oils. This eco-friendly choice effectively kills bed bugs on contact while providing a safer application for families and pets.
User feedback highlights its pleasant scent and effectiveness in smaller infestations. Like many plant-based options, it might require multiple applications for severe cases.
- Kill bed bugs, bed bug eggs, fleas and ticks with Ortho Home Defense Max Bed Bug, Flea & Tick Killer
- This bed bug spray kills even the toughest bed bugs (pyrethroid-resistant bed bugs)
- Use this indoor bug killer as a spot treatment around bed frames, baseboards and mattress seams, tufts and folds
- Apply insect spray using the included Comfort Wand to target tight and hard-to-reach places where bed bugs hide
- Ortho Home Defense Max Bed Bug, Flea & Tick Killer is a Step 2 product in the Ortho Bed Bug Solution System; use with Step 1: Detect and Trap and Step 3: Cracks and Crevices products for best results
9. Raid Bed Bug Detector and Killer
Raid Bed Bug Detector and Killer is a highly recognizable option in the pest control world. This product offers a dual action — it kills bed bugs on contact and sets up a barrier to prevent new ones.
The fast-acting formula makes it efficient for tackling infestations, while its easy spray nozzle allows for thorough application. Users appreciate the ability to see visible results quickly.
However, it is less eco-friendly compared to some other options, which could deter environmentally conscious consumers.
- Partially enclosed trap, designed with a see-through window, enables consumers to identify bugs easily
- Use when traveling or at home
- Indoor use
- Disposable detector
- Raid Bed Bug Detector and Trap, 4 count
10. Vamoose Bed Bug Killer
Vamoose Bed Bug Killer is an excellent choice for comprehensive coverage. This product uses a bio-insecticide that effectively kills bed bugs while remaining non-toxic.
Users report its unique spray mechanism allows for precise application, infiltrating beds and crevices where bed bugs may reside. While it’s well-rated, some users mention it may not provide a residual effect, necessitating reapplications.
- Kill bed bugs, bed bug eggs, fleas and ticks with Ortho Home Defense Max Bed Bug, Flea & Tick Killer
- This bed bug spray kills even the toughest bed bugs (pyrethroid-resistant bed bugs)
- Use this indoor bug killer as a spot treatment around bed frames, baseboards and mattress seams, tufts and folds
- Apply insect spray using the included Comfort Wand to target tight and hard-to-reach places where bed bugs hide
- Ortho Home Defense Max Bed Bug, Flea & Tick Killer is a Step 2 product in the Ortho Bed Bug Solution System; use with Step 1: Detect and Trap and Step 3: Cracks and Crevices products for best results
Conclusion
Finding the best bed bug spray can dramatically improve your chances of eradicating an infestation. The products mentioned in this article each come with their unique attributes, offering options for different needs and situations. Always consider your conditions and personal preferences when selecting the best bed bug spray for your household. Remember to read reviews and follow instructions for optimal results, ensuring a bug-free living environment.
With the right approach and the best bed bug spray in hand, you’ll be well-equipped to tackle any bed bug issue that comes your way in 2025.
Last update on 2025-12-26 / Affiliate links / Images from Amazon Product Advertising API | hishecozy.com is a participant in the Amazon Associate program and will earn from qualifying purchases.
