When it comes to pain management, the best numbing creams can provide instant relief for various skin irritations, procedures, or injuries. In this article, we’ll explore the top 10 numbing creams available on Amazon in 2025, ensuring you have the best options for your needs. Whether you’re preparing for a tattoo, laser treatment, or just need relief from pain, these products are highly rated and ready to help.
Bestseller No. 1
Ebanel 5% Lidocaine Numbing Cream, Pain Relief Burn Itch Numb Cream, Maximum Strength Topical Anesthetic with Allantoin, Vitamin E for Local and Anorectal Uses, Hemorrhoid Treatment, 1.35 Oz
- FSA HSA Eligible OTC Medications & Treatments - This topical lidocaine numb cream with Allantoin, clinically proven to temporarily relieve pain, burning, itching, and discomfort, reduces inflammation and soreness in local and anorectal areas
- 5% Lidocaine Cream Maximum Strength - This pain relief anti itch cream provides immediate relief for minor aches, minor burns, and minor skin irritations. It also works for postpartum relief, hemorrhoid shrinking treatment, and anorectal disorders
- Enhanced Liposomal Deep Penetrating Skin Numbing Cream - Best efficacy, fast-acting & long-lasting. It begins numbing in 3-5 minutes, peaks after 20-25 minutes, and lasts 1 hour from its peak. Numbing performance may vary depending on the thickness of the skin area and individual metabolism
- Oil-Free, Odor-Free & Non-Greasy - Hypoallergenic, no harsh chemicals, non-addictive. Apply before, during, and after treatment, may reapply halfway for enhanced effect. Water-based formula for easy application and no-mess removal
- Made in USA in an FDA Registered Facility - Cruelty-Free, cGMP Certified, secured with a child-resistant cap. A performance test before treatment is highly recommended to assess your best performance timing
Bestseller No. 2
Treatonic Maximum Strength Numbing Cream: Numbing Cream for Discomfort, Burn, Itch & Pain Relief - Fast-Acting, Soothing Topical Anesthetic with Menthol & Emu Oil for Hemorrhoid Treatment – 1.7oz
- Maximum Relief Numbing Cream: Formulated with maximum strength topic anesthetic. Relieves pain and itching associated with minor aches, burns, and skin irritations. Also effective for soothing itch from insect bites and provides comfort for hemorrhoids, and anorectal conditions.
- Supports Skin with Healing Ingredients: With skin-loving ingredients like Vitamin E, Emu oil, and Arnica, this formula helps hydrate, protect, and soothe delicate skin. A great option for areas experiencing occasional sensitivity or minor external stress.
- Fast-Absorbing, Long-Lasting Comfort: Our lightweight cream absorbs quickly and starts working within minute, numbing effect begins in 10 minutes, and peak effect in 45-60 minutes. It delivers extended comfort to areas of mild irritation, helping you get back to your day with ease.
- Non-Greasy & Fragrance-Free: This water-based formula goes on smoothly without leaving behind residue or stickiness. It’s free from added fragrances and dyes, making it suitable for sensitive skin types.
- Secure Packaging with Safety Cap: This cream comes in a child-resistant package designed to protect against unintentional opening. Easy to use and safely stored when not in use.
OFF -$4.01Bestseller No. 3
Aspercreme Lidocaine Pain Relief Cream Soothes Aggravated Nerves, Numbing Topical Analgesic with Max-Strength 4% Lidocaine & Moisturizing Aloe, 4.3 Oz.
- Contains one (1) 4.3-oz. tube of Aspercreme Pain Relief Cream With Max-Strength Lidocaine and Moisturizing Aloe
- Fast-Acting Relief: Experience rapid and lasting pain relief with max-strength 4% lidocaine topical numbing cream, designed to target nerves and numb away pain
- Non-greasy Formula: Fragrance-free Aspercreme moisturizes and relieves without greasy residue or strong odor
- Maximum-Strength Lidocaine: OTC Aspercreme offers the maximum-strength lidocaine pain relief available without a prescription and is FSA/HSA eligible
- Travel-Size: Take your pain relief solution on the go in a compact and portable tube
Bestseller No. 5
WELMATE 5% Lidocaine Cream for Hemorrhoids – Fast-Acting Lidocaine Numbing Cream & Topical Analgesic Cream for Anorectal Itch Relief, Unscented, Child Resistant Packaging 1 oz (30g)
- Fast Acting Hemorrhoid Cream - Made with 5% Lidocaine, this topical anesthetic provides temporary relief from discomfort, itching, and burning associated with hemorrhoids and other anorectal irritation.
- Maximum Strength Lidocaine Cream - Delivers doctor-recommended strength with the highest percentage of Lidocaine available over the counter to help soothe targeted external discomfort fast.
- External Use Only, Made for Sensitive Skin - Formulated for delicate areas, this cream is designed for external, anorectal use and is gentle on all skin types. Packaging is child-resistant for added peace of mind.
- How to Use - Clean the area with soap and water, rinse thoroughly, and pat dry. Apply external pain relief cream up to 6 times per day. Our cream is cruelty-free, non-greasy, odorless, and free from harsh chemicals.How to Use - Clean the area with soap and water, rinse thoroughly, and pat dry. Apply external pain relief cream up to 6 times per day. Our cream is cruelty-free, non-greasy, odorless, and free from harsh chemicals.
- Why WELMATE? - Founded in 2020 by former pharmacy employees who were fed up with the pricing of over-the-counter medication. Today, we continue to bring affordable health and wellness products to your doorstep as America's trusted OTC store.
Bestseller No. 6
Ebanel 5% Lidocaine Numbing Cream, 2-Pack Pain Relief Burn Itch Numb Cream, Maximum Strength Topical Anesthetic with Allantoin, Vitamin E for Local and Anorectal Uses, Hemorrhoid Treatment
- FSA HSA Eligible OTC Medications & Treatments - This topical lidocaine numb cream with Allantoin, clinically proven to temporarily relieve pain, burning, itching, and discomfort, reduces inflammation and soreness in local and anorectal areas
- 5% Lidocaine Cream Maximum Strength - This pain relief anti itch cream provides immediate relief for minor aches, minor burns, and minor skin irritations. It also works for postpartum relief, hemorrhoid shrinking treatment, and anorectal disorders
- Enhanced Liposomal Deep Penetrating Skin Numbing Cream - Best efficacy, fast-acting & long-lasting. It begins numbing in 3-5 minutes, peaks after 20-25 minutes, and lasts 1 hour from its peak. Numbing performance may vary depending on the thickness of the skin area and individual metabolism
- Oil-Free, Odor-Free & Non-Greasy - Hypoallergenic, no harsh chemicals, non-addictive. Apply before, during, and after treatment, may reapply halfway for enhanced effect. Water-based formula for easy application and no-mess removal
- Made in USA in an FDA Registered Facility - Cruelty-Free, cGMP Certified, secured with a child-resistant cap. A performance test before treatment is highly recommended to assess your best performance timing
Bestseller No. 7
Curist 5% Lidocaine Cream Topical Pain Relief - Numb Quickly & Effectively with 5% Lidocaine Numbing Cream - (1 Pack - 2 oz Jar)
- LIDOCAINE 5% PAIN CREAM | Experience deep pain relief with the strongest formulation of topical lidocaine available OTC.
- A fast pain relief, anti itch, and numb cream - made with the highest quality ingredients without the typical pharmacy mark-up.
- TREAT, NUMB & SOOTH ALL-IN-ONE | Our soothing, numbing cream provides fast relief from pain, itching, burning, discomfort & irritation by blocking the nerves and desensitizing. Numbing relief for hemorrhoids and other anorectal issues.
- CURIST PAIN RELIEF CREAM | Stronger tha Aspercreme 4% Lidocaine, which is typically used for muscle pain and as a numbing cream.
- EASY ACCESS JAR | Light, whipped formula for easy application. Get numbing relief at a fraction of the cost. For external use only.
What to Look for in a Numbing Cream
Before diving into our top picks, let’s discuss what to consider when searching for the best numbing cream:
Ingredients
Look for creams that contain effective anesthetic agents like lidocaine or benzocaine, as these are well-known for their numbing properties.
Application Time
Some creams provide quick results within minutes, while others may take longer. Be sure to choose one that fits your timeline.
Skin Type
Different creams work better on various skin types. If you have sensitive skin, look for hypoallergenic options.
Purpose
Identifying the primary purpose of the cream (tattoo, laser hair removal, or general pain relief) can dictate your best choice.
Reviews
Customer feedback can give insights into a product’s efficacy and safety.
Now, let’s delve into our top 10 numbing creams available on Amazon!
1. Bactine Max Pain Relieving Cleansing Spray
Bactine Max is not only a numbing cream but also a cleansing spray. Its powerful formula features lidocaine that effectively numbs the affected area while cleansing minor cuts and scrapes. It’s suitable for children and adults alike.
Pros
- Quick-acting relief
- Antiseptic formula
- Easy to apply spray bottle
Cons
- May require frequent applications for prolonged pain
- Might not be suitable for large areas
Bestseller No. 1
Bactine Max Pain Relieving Antiseptic Spray with Lidocaine, First Aid Pain + Itch Relief, No-Sting, Kills 99% of Germs*, 5oz
- Bactine Max Pain Relieving Antiseptic Spray with Lidocaine, First Aid Pain + Itch Relief, No-Sting, Kills 99% of Germs*, 5oz
- Pain Relief + Skin Infection Protection --- Get a better value than tiny tubes of ointment. Bactine Max Pain Relieving Spray is an antiseptic minor wound, burn, and bug bite cleanser that provides immediate pain relief + itch relief. All while protecting against infection.
- Kills 99% of Germs --- Feel confident knowing you are protected. Bactine Max uses benzalkonium chloride and effectively kills 99% of germs associated with skin infections. It stops the growth of bacterial microorganisms on the skin to prevent infection of wounds, burns, and insect bites.
- Max Strength Pain Relief --- Boo-boos hurt enough. Why add to that? Formulated with 4% Lidocaine, a topical analgesic, that numbs the pain. It interferes with the transmission of nerve pain signals from the site of application. It has the maximum lidocaine amount allowed by the FDA for OTC products for local anesthetics.
- No-Sting Means No Worries --- Treat your family with a tear free first aid wound care. Unlike other hydrogen peroxide or alcohol based wound care products, Bactine cleanses and protects without a painful, harsh sting. It provides temporary relief of pain and itching from minor wounds, bug bites, and burns. It won't leave a brown stain on skin like iodine-based products.
2. Numb Master Lidocaine 5% Cream
Numb Master’s formula contains the maximum allowed concentration of lidocaine. This makes it one of the most potent numbing creams on the market, suitable for use before tattoos, procedures, and chronic pain areas.
Pros
- High lidocaine concentration
- Long-lasting effect (up to 2 hours)
- Non-greasy texture
Cons
- Not suitable for sensitive skin
- Can cause some irritation if overused
Bestseller No. 1
Clinical Resolution Numb Master 5% Lidocaine Numbing Cream for Pain Relief, Topical Anesthetic Burn Itch Cream Maximum Strength, Fast Acting Hemorrhoid Treatment with Vitamin E and Aloe, 1.25 Oz
- 5% TOPICAL LIDOCAINE PAIN RELIEF – 5% Lidocaine Numbing Cream Maximum Strength Topical Pain Relief - This anti burn itch cream provides rapid pain relief for minor aches, minor cuts, minor scrapes, sunburn, scrapes and minor skin irritations. It also works for mosquito bite itch relief, bug bite itch relief, insect bite relief, postpartum relief, hemorrhoid shrinking treatment, and anorectal disorders.
- LONG LASTING & QUICK RELIEF - Enhanced Liposomal Deep Penetrating Skin Numbing Cream - Best efficacy, fast-acting & long-lasting. It begins numbing in 3-5 minutes, peaks after 20-25 minutes, and lasts 1 hour from its peak. Numbing performance may vary depending on the thickness of the skin area and individual metabolism
- NON-OILY & NON-GREASY - Oil-Free, Odor-Free & Non-Greasy - Hypoallergenic, no harsh chemicals, non-addictive. Apply before, during, and after treatment, may reapply halfway for enhanced effect. Water-based formula for easy application and no-mess removal.
- FSA HSA Eligible OTC Medications & Treatments - This topical lidocaine numb cream with Allantoin, clinically proven to temporarily relieve pain, burning, itching, and discomfort, reduces inflammation and soreness in local and anorectal areas
- Made in USA in an FDA Registered Facility - Cruelty-Free, cGMP Certified, secured with a child-resistant cap. A performance test before treatment is highly recommended to assess your best performance timing
3. Dr. Numb Lidocaine 4% Cream
Dr. Numb is a popular choice for tattoo artists and people undergoing minor surgical procedures. Its formula is enriched with aloe vera and vitamin E, helping to soothe and moisturize the skin as it numbs.
Pros
- Enriched with skin-beneficial ingredients
- Works within 20 minutes
- Paraben-free
Cons
- Effects may not last as long as higher concentration creams
- Requires a thicker application
Bestseller No. 1
Dr. Numb 4% Lidocaine Cream – Topical Anorectal for Temporary Relief of Hemorrhoid and Local Discomfort – with Vitamin E – 30g (1 Pack)
- Uses: For temporary relief of local discomfort, itching, soreness or burning in the perianal area associated with anorectal disorders.
- Ingredients: Active Ingredient- Lidocaine. Inactive Ingredients- Carbopol, Lecithin, Propylene Glycol, Tocopheryl Acetate, Benzyl Alcohol, Water
- Direction: Adults and Children 12 years and older: When practical, cleanse the affected area with mild soap and warm water and rinse thoroughly. Gently dry by patting or blotting with toilet tissue or a soft cloth before application of this product. Apply to the affected area up to 6 times a day. Children under 12 years: Consult a doctor.
4. Hush Anesthetic Numbing Gel
Hush Numbing Gel is well-received among tattoo artists for its fast-acting formula. This gel provides relief within 20 minutes and is easy to clean off after use.
Pros
- Works quickly
- Water-based, making it easier to clean
- Non-oily finish
Cons
- May not penetrate deeply for all procedures
- Requires a generous layer for maximum effectiveness
No products found.
5. Topicaine 5% Lidocaine Gel
Topicaine is a topical anesthetic that effectively numbs the skin for minor procedures. Its gel consistency makes it easy to apply, and it’s designed to penetrate quickly into the skin.
Pros
- Gel formula for easy application
- Non-oily
- Quick-acting
Cons
- May stain clothing
- Some users report a burning sensation upon application
6. Aspercreme Pain Relieving Cream
Aspercreme is a well-known brand, especially for muscle pain relief. Its formula uses trolamine salicylate instead of lidocaine, making it an excellent option for individuals sensitive to anesthetics.
Pros
- Non-greasy formula
- Multiple uses (muscle soreness, minor aches)
- No mess application
Cons
- Slower to numb than lidocaine-based creams
- Might require more frequent applications
OFF -$4.01Bestseller No. 1
Aspercreme Lidocaine Pain Relief Cream Soothes Aggravated Nerves, Numbing Topical Analgesic with Max-Strength 4% Lidocaine & Moisturizing Aloe, 4.3 Oz.
- Contains one (1) 4.3-oz. tube of Aspercreme Pain Relief Cream With Max-Strength Lidocaine and Moisturizing Aloe
- Fast-Acting Relief: Experience rapid and lasting pain relief with max-strength 4% lidocaine topical numbing cream, designed to target nerves and numb away pain
- Non-greasy Formula: Fragrance-free Aspercreme moisturizes and relieves without greasy residue or strong odor
- Maximum-Strength Lidocaine: OTC Aspercreme offers the maximum-strength lidocaine pain relief available without a prescription and is FSA/HSA eligible
- Travel-Size: Take your pain relief solution on the go in a compact and portable tube
7. Zensa Numbing Cream
Zensa Numbing Cream contains lidocaine and is specifically formulated for procedures like tattoos, body piercings, and laser treatments. It’s a favorite among professionals due to its efficacy and minimal skin irritation.
Pros
- Water-based formula
- Strong, lasting numbing effect
- Vegan and cruelty-free
Cons
- Higher price point
- Application may take longer for optimal results
Bestseller No. 1
Zensa Numbing Cream 5% Lidocaine, Maximum Strength Topical Anesthetic-Pain Relief, Fast-Absorbing, Long-Lasting, Hypoallergenic Water-Based with Vitamin E, Vegan, Cruelty-Free, 30g, NDC 69805-786-01
- For the temporary relief of local discomfort associated with anorectal disorders. For the temporary relief of pain, soreness and burning.
8. Numbify Numbing Cream
Numbify is another lidocaine-based cream that provides numbing relief for minor cuts, scrapes, and insect stings. It’s designed to soothe while it numbs.
Pros
- Paraben-free and non-greasy
- Fast-acting
- Ideal for sensitive skin
Cons
- Some find the effect doesn’t last long enough
- Requires thick application for maximum effectiveness
Bestseller No. 1
Clinical Resolution Numb Master 5% Lidocaine Numbing Cream for Pain Relief, Topical Anesthetic Burn Itch Cream Maximum Strength, Fast Acting Hemorrhoid Treatment with Vitamin E and Aloe, 1.25 Oz
- 5% TOPICAL LIDOCAINE PAIN RELIEF – 5% Lidocaine Numbing Cream Maximum Strength Topical Pain Relief - This anti burn itch cream provides rapid pain relief for minor aches, minor cuts, minor scrapes, sunburn, scrapes and minor skin irritations. It also works for mosquito bite itch relief, bug bite itch relief, insect bite relief, postpartum relief, hemorrhoid shrinking treatment, and anorectal disorders.
- LONG LASTING & QUICK RELIEF - Enhanced Liposomal Deep Penetrating Skin Numbing Cream - Best efficacy, fast-acting & long-lasting. It begins numbing in 3-5 minutes, peaks after 20-25 minutes, and lasts 1 hour from its peak. Numbing performance may vary depending on the thickness of the skin area and individual metabolism
- NON-OILY & NON-GREASY - Oil-Free, Odor-Free & Non-Greasy - Hypoallergenic, no harsh chemicals, non-addictive. Apply before, during, and after treatment, may reapply halfway for enhanced effect. Water-based formula for easy application and no-mess removal.
- FSA HSA Eligible OTC Medications & Treatments - This topical lidocaine numb cream with Allantoin, clinically proven to temporarily relieve pain, burning, itching, and discomfort, reduces inflammation and soreness in local and anorectal areas
- Made in USA in an FDA Registered Facility - Cruelty-Free, cGMP Certified, secured with a child-resistant cap. A performance test before treatment is highly recommended to assess your best performance timing
9. Lidocaine Plus Maximum Strength Cream
As the name suggests, this cream features a potent lidocaine concentration, making it an effective choice for quick pain relief. It is particularly well-suited for waxing, laser treatments, and other procedures.
Pros
- Fast-acting with long-lasting relief
- Great for larger areas
- Non-greasy formula
Cons
- Can be irritating for sensitive skin
- Might be difficult to find at local stores
Bestseller No. 1
HealthWise Lidocaine Plus+ Cream | Numbs Away Pain | | Non-Greasy | 3.0 Oz | 4% OTC Lidocaine + 10% Benzyl Alcohol | Topical Anesthetic
- MAXIMUM STRENGTH RELIEF — Provides temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backaches, strains, sprains and bruises; apply directly to the skin
- PAIN RELIEVING LIDOCAINE + BENZYL ALCOHOL — Powerful pain relief ingredients: 4% lidocaine plus 10% benzyl alcohol work together by desensitizing the nerves, effectively numbing the pain where the cream is applied with no irritation and no burning
- NON-GREASY FORMULA — Non-greasy formula goes on smooth; safely apply 3-4 times daily
- 30-APPLICATIONS PER TUBE — Only a dime size of cream is needed per application to targeted areas for up to 30 applications in each tube
- SUPPORT AND INSTRUCTION — Follow the detailed use instructions, as well as the warnings and cautions, before use; use only as directed, instructions are easy to follow and use
10. EMLA Cream (Lidocaine and Prilocaine)
EMLA Cream is a prescription-strength product that combines lidocaine and prilocaine for effective numbing. It’s typically used prior to minor surgical procedures to alleviate pain.
Pros
- Excellent for deeper tissue numbing
- Medical-grade effectiveness
- Duration can last up to 4 hours
Cons
- Requires prescription in some areas
- Higher cost compared to over-the-counter options
Bestseller No. 1
5% Lidocaine Topical Numbing Cream: Maximum Strength Topical Anesthetic Numb Cream for Pain Relief, Itching, Burning, Soreness, Hemorrhoid - Fast Acting & Long Lasting Numbing Formulation - 2.1 oz
- 5% Lidocaine Cream Maximum Strength Formula: Formulated with 5% lidocaine, this topical cream provides temporary relief from localized discomfort such as itching, burning, or minor skin irritation. A powerful solution for external use when your skin needs extra care.
- Fast-Acting and Long-Lasting: This lidocaine cream begins to work within minutes, numbing effect begins in 10 minutes, and peak effect in 45-60 minutes. Effects can last for hours, offering extended comfort throughout your daily routine. Numbing performance may vary depending on skin type and treatment area.
- Enriched with Soothing Ingredients: Infused with Vitamin E, Emu Oil, and Allantoin, this formula supports skin hydration and comfort while helping to calm sensitive or stressed areas.
- Fast-Absorbing, Non-Greasy & Gentle on Skin: This lightweight, water-based cream absorbs quickly into the skin, leaving no oily residue behind. Fragrance-free and suitable for sensitive skin types, it’s designed for easy, mess-free application and everyday comfort.
- Secure, Child-Resistant Packaging: Packaged with a tamper-evident, child-resistant safety cap to reduce accidental access. Easy to carry and store for use whenever temporary relief is needed.
Conclusion
Choosing the best numbing cream can make a significant difference in pain management, whether for personal care, medical procedures, or DIY projects. Be sure to consider the specific needs for your application, and don’t hesitate to consult with a healthcare professional if you have questions about which product will work best for you.
In summary, whether you’re looking for quick relief from everyday pain or preparing for a more significant procedure, the creams listed above stand out as the best options available on Amazon in 2025. Each has unique strengths, so consider your specific needs when making a selection.
Keep in mind that while numbing creams can effectively alleviate pain, always follow the application instructions and consider any personal skin sensitivities. With the right product, you can ensure a more comfortable experience.
Keywords:
best numbing cream, numbing cream for tattoos, numbing ointment, pain relief cream.
Feel free to explore these items on Amazon to find the best numbing cream for your needs!
Last update on 2025-12-25 / Affiliate links / Images from Amazon Product Advertising API | hishecozy.com is a participant in the Amazon Associate program and will earn from qualifying purchases.
