When it comes to maintaining a clean home, especially for pet owners, finding the right cleaning products is essential. One of the most effective solutions for tackling stubborn stains and odors caused by pets is enzyme cleaners. These cleaners utilize natural enzymes to break down organic matter, making them particularly effective against pet messes. In this article, we will explore the 10 best enzyme cleaners available on Amazon in 2024, along with a buying guide to help you choose the right product for your needs.
Bestseller No. 1
AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack
- 1 gallon bottle of multi-purpose enzyme cleaning solution for a wide variety of surfaces and environments
- Breaks up complex organic proteins, pet smells and stains, hair, grease, oils, and more for effective results
- Ideal for commercial properties, retail, and hospitality
- Use as needed on stains and problem areas for spot cleaning carpet, surfaces, drains, toilets, grease traps, and more
Bestseller No. 2
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz
- Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
- Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
- Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
- Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
- Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx
Bestseller No. 3
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
- THE POWER OF ONE: This versatile product is the only probiotic cleaner you need, providing powerful cleaning performance in a wide variety of applications. Multipurpose use: Maintain clean drain lines and septic tanks to prevent clogs and potential buildup. Clean and deodorize trash bins, stains and odors on floors, carpets, bathroom surfaces, kitchen surfaces, and more.
- ACTIVE UP TO 21 DAYS: Our specialized probiotics continue to clean soils in cracks, grout and tough to reach places. Simply spray & let the probiotics do the dirty work!
- NATURALLY, SUPERIOR RESULTS: A special blend of enzyme-producing probiotics break down complex proteins, fats, oils, greases, and other organic waste. The enzymes digest the soils until they have been eliminated, providing a long-lasting, continuous clean without leaving a residue or harmful by-products behind.
- ELIMINATE ODOR: Provide total odor control by eliminating the actual source of even the most pungent organic malodors naturally, including rotting food, urine, feces, vomit, and trash. Plus, the fresh lemon and sage fragrance leaves behind a light, pleasant scent that rejuvenates the air of any environment.
- MADE IN THE USA - 1 Gallon Bottle
Bestseller No. 4
Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula
- SPOT STAIN & ODOR REMOVER: Begins to break down and remove stains immediately on contact.
- LIGHT CITRUS SCENT: Dog odor control formula gets your home smelling clean again.
- ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
- TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
- SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets.
Bestseller No. 5
Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads
- Powerful Bio Enzymatic Cleaner: ACTIVE Laundry Odor Removers Boost your normal laundry detergent to effectively target Stains & Odors, not mask them like washing soda or in-wash scent boosters. It uses Lab-proven Biological Cleaning to remove laundry odor & strong smell
- Heavy Duty Stain Remover for clothes: Our Enzyme Laundry Additive Powder is formulated for Stain Removal of dirty clothes, perfect for Funk, Grease, Armpit Sweat stain, Blood stain, Oil and more!
- Gentle on All Fabrics: Our Fragrance Free Laundry Boost Plant-based Formula uses zero harsh chemicals. Natural enhancer for whites & colors. Even safe for pesky activewear fabrics
- Value 64 Load Package: ACTIVE Enzyme Cleaner Concentrated 32-oz size is good for 64 Loads compared to other products with 1 lb or less
- Compatible with all Washers & Detergents: Add Laundry Booster Powder to your usual detergent & cleaners! HE, Front & Top load Washer Approved. Also use as laundry soak pretreat powder in order to treat set-in stain
Bestseller No. 6
Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce - Fragrance Free
- Pro Grade Clean - Zeiff Pro-Grade Formulas are innovative, unique proprietary solutions, trusted by professionals and consumers for being the most effective cleaning products to get the job done. Whether you’re a pro or just expect pro-grade results, Zeiff delivers Pro Grade Clean
- Powerful Cleaning Performance - Our proprietary formulation breaks up complex organic proteins, pet stains, hair, grease, fats, and oils, easily cutting through dirt, grease and grime without leaving any visible residue. Don't just expect clean, expect Zeiff Clean! You'll know it when you see it, clean you didn't even know exists
- Multi-Purpose Enzyme Cleaner - The special blend of bacterial enzymes, detergent and deodorant, prevents clogging in drains, grease traps, septic tanks, drain lines and downpipes, and cleans stains, odors, carpets, floors, kitchen & bathroom surfaces, and much more. Ideal for Professional and Home use
- Deodorizer & Odor Eliminator - Highly concentrated bacterial digestant for grease, stains, oils, & organic waste. Effectively eliminates foul odors caused by urine, feces, blood, vomit, food, garbage and grease, leaves long-lasting freshness
- Safe & Effective - Zeiff Pro Grade Formulas are safe & effective, non-corrosive, non-flammable, non-acidic, free of caustics and dyes, pH neutral, paraben-free, pet safe, cruelty-free. Proudly made in the USA
Bestseller No. 7
Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz
- PET STAIN AND ODOR REMOVER: Things can get a little messy when your pet is involved - that’s where we come in; This extra-strength cleaning solution is specially formulated to tackle the toughest smells & dirtiest spots left behind by your beloved pets.
- EXTREME ENZYMATIC CLEANER: This professional strength spray consists of a powerful enzyme formula three times stronger than our regular formula, specialized for breaking down, eliminating, and permanently neutralizing both new and old stains and odors.
- FOR DOGS AND CATS: Say goodbye to bad messes - This dog and cat-specific cleaning spray is the best thing for cleaning up after urine, feces, vomit, and all the stains and smells that accompany them; It is a pet-safe and family-friendly cleaning option
- MULTIFUNCTION SPRAY: This cleaner can be used for carpets, upholstery, bedding, fabric toys, clothing, & other water-safe surfaces in your home; It uses a patented 3-in-1 nozzle with mist, foam, and stream features so you can pick the best way to clean up
- SIMPLE SOLUTION: it’s just that…a simple solution to all of your pets’ messes – wherever they may be; We offer easy-to-use, no-hassle products that will effectively help you keep your home clean and sparkling; In short - pet parenting made easy.
Bestseller No. 8
biokleen Bac Out Stain & Odor Eliminator with Live Enzyme Cultures, 32 oz
- biokleen Bac Out Stain & Odor Eliminator with Live Enzyme Cultures, 32 oz
Bestseller No. 9
OdoBan Disinfectant Concentrate and Odor Eliminator, Made in the USA, Original Eucalyptus Scent, 1 Gallon
- Multi-Purpose: Our cleaning concentrate cleans, disinfects, freshens, and eliminates unpleasant stenches. This one-gallon jug features our original fresh eucalyptus scent.
- Multi-Surface: Our versatile formula can be used on many household surfaces, including upholstery, carpets, bedding, showers, walls, and floors.
- Multi-Use: Not only is our versatile cleaning and disinfecting formula effective, but it can double as an air freshener or even as a laundry refresher.
- Where to Use: Our sanitizing formula can be used in any setting including locker rooms, gyms, dressing rooms, shower areas, and more. It can be used in day cares, hospitals, healthcare facilities, cafeterias, restaurants, and public transportation.
- Directions: Use as directed on label. Spray 6-8 inches away from the surface. Clean with a sponge, brush, or cloth (do not breathe spray).
Bestseller No. 10
Green Gobbler Enzyme Drain Cleaner | Controls Foul Odors & Breaks Down Grease, Paper, Fat & Oil in Sewer Lines, Septic Tanks & Grease Traps | 1 Gallon
- ENZYME ENHANCED FORMULA: Green Gobbler Enzymatic Drain & Grease Trap Cleaner uses an enzyme enhanced formula to clear buildup and remove odors in grease traps, septic tanks and similar plumbing systems. It helps digests oils, fats, grease, sludge and other food waste within hours of application. This bottle uses anti-glug technology to help reduce splashing and provides up to eight treatments.
- SAFE FOR PIPES: Green Gobbler helps maintain drain lines, septic tanks, grease traps and grease interceptors. Our enzyme enhanced formula is an excellent alternative to sodium hydroxide and other caustic chemicals.
- IMPROVE GREASE TRAP EFFICIENCY: Green Gobbler increases the efficacy of grease traps by allowing enzymes & bacteria to work more efficiently to promote the separation of water and grease, helping your trap run more smoothly.
- KEEP SEPTIC TANKS HEALTHY: Green Gobbler helps prompt the biological breakdown of foul odors and organic material inside demanding environments such as drains, pipes and septic tanks.
- GREEN GOBBLER GUARANTEE: Green Gobbler cares about its customers. We take pride in developing innovative & effective products for your home or business. If for any reason you are unsatisfied, please contact us. We offer a money-back guarantee within 30 days of purchase.
What to Look for in Enzyme Cleaners
When shopping for enzyme cleaners, consider the following factors:
- Type of Stain: Ensure the cleaner is formulated for the specific type of stain you are dealing with, such as urine, feces, or food.
- Surface Compatibility: Check if the cleaner is safe for the surfaces you intend to use it on, including carpets, hardwood floors, and upholstery.
- Safety for Pets: Look for biodegradable and non-toxic formulas that are safe for use around pets.
- Ease of Use: Consider whether you prefer a spray bottle for easy application or a larger jug for more extensive cleaning tasks.
Top 10 Enzyme Cleaners on Amazon
1. Nature’s Miracle Dog Stain & Odor Remover
Nature’s Miracle is a trusted name in pet cleaning products. This enzyme cleaner effectively eliminates stains and odors caused by pet accidents. Its light citrus scent helps mask unpleasant odors while the enzymes work to break down the stains. Suitable for use on carpets, upholstery, and hard surfaces, this cleaner is a must-have for pet owners.
Bestseller No. 1
Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula
- SPOT STAIN & ODOR REMOVER: Begins to break down and remove stains immediately on contact.
- LIGHT CITRUS SCENT: Dog odor control formula gets your home smelling clean again.
- ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
- TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
- SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets.
2. Angry Orange Enzyme Cleaner and Pet Stain Remover Spray
Angry Orange is known for its powerful cleaning capabilities and delightful orange scent. This enzyme cleaner not only tackles pet stains but also leaves behind a fresh aroma. It works on various surfaces, including carpets and hardwood floors, making it a versatile choice for pet owners.
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3. Biokleen Bac Out Stain & Odor Eliminator
Biokleen’s Bac Out is an eco-friendly option that uses live enzyme cultures to eliminate tough stains and odors. This cleaner is particularly effective on carpets and upholstery, leaving behind a pleasant citrus scent. Its biodegradable formula makes it a great choice for environmentally conscious pet owners.
Bestseller No. 1
Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces
- STAIN AND ODOR REMOVER: Bac-Out safely works wonders on pet accidents, wine spills on carpets and couches, cloth diapers and pails, laundry, disposals, garbage cans and much more.
- PREFERRED BY PROFFESSIONALS: Bac-Out is the preferred choice of commercial carpet cleaners nationwide.
- BIO ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
- PLANT BASED CLEANER: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
- MADE IN THE USA: We use biodegradable ingredients, never test on animals, and are manufactured in the USA with US and imported parts
4. Rocco & Roxie Stain & Odor Remover
This professional-strength enzyme cleaner is highly rated for its effectiveness on both soft and hard surfaces. Rocco & Roxie’s formula works quickly to eliminate stains and odors, making it a favorite among pet owners. Its ability to tackle set-in stains makes it a reliable choice for any pet-related mess.
Bestseller No. 1
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz
- Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
- Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
- Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
- Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
- Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx
5. Bubba’s Super Strength Pet Stain and Odor Terminator
Bubba’s cleaner is designed for heavy-duty cleaning, making it ideal for tough pet stains. Its professional-grade formula uses natural dormant enzymes to break down stains and odors effectively. This cleaner is safe for use on carpets, upholstery, and hardwood floors.
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6. TriNova Natural Pet Stain & Odor Remover
TriNova’s enzyme cleaner is made from natural and organic ingredients, making it a safe choice for homes with pets. Its powerful formula effectively eliminates stains and odors without the use of harmful chemicals. This eco-friendly option is perfect for pet owners looking for a guilt-free cleaning solution.
Bestseller No. 1
TriNova Pet Stain and Odor Remover Eliminator - Advanced Enzyme Cleaner Spray - Remove Old & New Pet Stains & Smells for Dogs & Cats - All-Surface Safe - 32 OZ
- ✅ SAFE & TRANSPARENT – We believe in complete ingredient transparency, listing every component right on the label. Our formula is crafted with carefully selected ingredients to effectively tackle pet stains while being safe for your home and pets.
- PROFESSIONAL STRENGTH - TriNova's Pet Stain & Odor Remover features a blend of enzymes that tackle stains and odors at their root to clean and neutralize. The enzymes work to break down the stains, drying out and disintegrating when they're finished to restore your carpet to like-new condition.
- ✅ SAFE Around Kids & Pets - TriNova understands your pets frequent the spaces where you and your children spend the most time as well. Because of this, TriNova's Pet Stain & Odor Remover contains a formula that leaves surfaces safe for your kids to keep on playing without any worry about harmful chemicals or toxins.
- ✅ USE IT ANYWHERE - Use this pet stain remover on most surfaces such as bedding, mattress, cage, kennel, laundry, clothes, hardwood, litter box and more. Even use it for small animals like hamsters, rat, and mice cages
- ✅ 100% SATISFACTION GUARANTEE - We think you'll love our product, but if you don't just let us know and we'll refund your purchase price!
7. Simple Solution Extreme Pet Stain and Odor Remover
Simple Solution’s Extreme formula is three times stronger than their regular cleaner, making it ideal for tough stains and odors. It features a 3-in-1 nozzle sprayer that allows for foam, mist, and stream application, providing versatility for different cleaning tasks.
Bestseller No. 1
Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz
- PET STAIN AND ODOR REMOVER: Things can get a little messy when your pet is involved - that’s where we come in; This extra-strength cleaning solution is specially formulated to tackle the toughest smells & dirtiest spots left behind by your beloved pets.
- EXTREME ENZYMATIC CLEANER: This professional strength spray consists of a powerful enzyme formula three times stronger than our regular formula, specialized for breaking down, eliminating, and permanently neutralizing both new and old stains and odors.
- FOR DOGS AND CATS: Say goodbye to bad messes - This dog and cat-specific cleaning spray is the best thing for cleaning up after urine, feces, vomit, and all the stains and smells that accompany them; It is a pet-safe and family-friendly cleaning option
- MULTIFUNCTION SPRAY: This cleaner can be used for carpets, upholstery, bedding, fabric toys, clothing, & other water-safe surfaces in your home; It uses a patented 3-in-1 nozzle with mist, foam, and stream features so you can pick the best way to clean up
- SIMPLE SOLUTION: it’s just that…a simple solution to all of your pets’ messes – wherever they may be; We offer easy-to-use, no-hassle products that will effectively help you keep your home clean and sparkling; In short - pet parenting made easy.
8. OUT! PetCare Advanced Stain and Odor Remover
This enzyme cleaner is particularly effective on pet urine, using a high concentration of pro-bacteria and enzymes to eliminate stains and odors. OUT! PetCare’s formula also helps prevent future incidents by erasing pheromones released during urination.
Bestseller No. 1
OUT! PetCare Pet Odor & Stain Remover Spray, Carpet & Floor Cleaner, Deodorizer for Dogs & Cats, Made in USA, 32 fl oz (2 Pack)
- PET STAIN AND ODOR ELIMINATOR: Tackle tough messes with this powerful dog enzymatic cleaner, designed to remove stains and odors from carpet, upholstery, and more; It works as a cat urine odor remover and dog pee cleaner to keep your home fresh
- DOG STAIN CLEANER: This powerful dog enzyme cleaner breaks down urine, vomit, feces, and more on carpets, upholstery, and floors; As a dog pee remover and carpet stain and odor remover, it tackles tough messes, leaving your home fresh and clean
- CARPET STAIN REMOVER SPRAY: Designed for water-safe surfaces, this carpet cleaner for pets removes tough stains and odors from rugs, upholstery, and bedding; As a carpet deodorizer and pet stain remover, it helps eliminate cat pee and dog messes
- PET CLEANER AND DETERRENT: This dog cleaning spray removes stains and odors while tackling pheromones to prevent repeat accidents; As a cat pee cleaner, it’s a safe, effective solution for maintaining a fresh, pet-friendly home
- OUT!: We’re here to providing pet parents with safe, affordable pet care that work; From dog cleaning supplies to puppy essentials, OUT! delivers solutions you can trust; Keep loving your pets, and we’ll handle the mess with dependable cleaning power
9. Shop Care 4X Ultra Synergistic Enzyme Laundry Detergent
For pet owners dealing with soiled laundry, Shop Care’s enzyme laundry detergent is a game-changer. This super-concentrated formula effectively removes tough stains and odors from all types of washable materials, leaving your laundry fresh and clean.
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10. BioTurf BioS+ Artificial Turf Pet Odor Eliminator
If you have artificial turf in your yard, BioTurf’s enzyme cleaner is designed specifically for outdoor use. It effectively eliminates pet odors and stains while being safe for plants. The included sprayer makes application easy and convenient.
Bestseller No. 1
BioTurf BioS+ Odor Eliminator Concentrate - Artificial Turf Cleaner for Dog Urine & Feces - Outdoor Yard Deodorizer Enzyme Odor Eliminator for Fake Grass, Patios, Kennels & Gravel - 1 Gallon
- Includes 1 Gallon Bio-Enzymatic Concentrate: Each bottle contains one gallon of BioS+ concentrated formula designed to make multiple gallons of cleaning solution. This powerful enzymatic cleaner specifically targets and digests the source of odors from dog urine, feces, and organic waste, effectively neutralizing smells rather than just masking them.
- Eliminates Urine & Feces Odors on Any Surface: Powered by active enzymes, BioS+ digests the source of smells—including ammonia and organic waste from poop—rather than masking them. It is highly effective on artificial grass, real grass lawns, gravel dog runs, concrete patios, and kennels without damaging the surface material.
- Safe for Pets, Kids & Plants: Formulated with non-toxic, plant-based ingredients, this outdoor odor eliminator is safe to use around playing children and pets immediately after use. It will not burn lawn grass, harm garden plants, or leave sticky chemical residue on paws, making it a safe choice for residential yards and professional doggy daycares.
- Application Schedule & Rain Resistance: For best results, spray the yard every 2 to 4 weeks, or more frequently in high-traffic multi-dog areas. While light moisture helps activate the enzymes, heavy rain may shorten the lifespan between treatments. If you live in a heavy rain area, apply after the weather clears to ensure deep penetration into the turf backing.
- Versatile Indoor/Outdoor Use & Combo Cleaning: This concentrate can be diluted for use on indoor carpets, tile, and cat litter boxes to neutralize ammonia. For ultimate odor control in severe cases, use BioS+ spray for immediate deep cleaning and pair it with BioTurf Granules (sold separately) to extend freshness between liquid applications.
Conclusion
Choosing the right enzyme cleaner can make a significant difference in maintaining a clean and odor-free home, especially for pet owners. The products listed above are some of the best options available on Amazon in 2024, each with unique features to cater to different cleaning needs. By considering the factors outlined in the buying guide, you can select the perfect enzyme cleaner to tackle any pet-related mess.
Last update on 2026-03-16 / Affiliate links / Images from Amazon Product Advertising API | hishecozy.com is a participant in the Amazon Associate program and will earn from qualifying purchases.
